NMDA PROCESSES MEDIATE ANTEROGRADE AMNESIA OF CONTEXTUAL FEAR CONDITIONING INDUCED BY HIPPOCAMPAL DAMAGE - IMMUNIZATION AGAINST AMNESIA BY CONTEXT PREEXPOSURE
NMDA PROCESSES MEDIATE ANTEROGRADE AMNESIA OF CONTEXTUAL FEAR CONDITIONING INDUCED BY HIPPOCAMPAL DAMAGE - IMMUNIZATION AGAINST AMNESIA BY CONTEXT PREEXPOSURE
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DOI：
10.1037/0735-7044.108.1.19
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发表时间：
1994-02-01
影响因子：
1.9
通讯作者：
FANSELOW, MS
中科院分区：
文献类型：
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作者：
YOUNG, SL;BOHENEK, DL;FANSELOW, MS
大鼠海马损伤会产生情境恐惧条件反射的逆行性和顺行性遗忘症。本实验检查了情境调节中的顺行缺陷。当手术后 7、14 或 28 天进行训练时，电解性海马损伤产生的缺陷很明显，证实了遗忘症的持久性。海马在情境调节中的作用可能与 NMDA（N-甲基-D-天冬氨酸）受体介导的过程有关。 NMDA 海马损伤和 NMDA 拮抗剂的海马内给药都会产生顺行性遗忘。在海马损伤前 28 天预先暴露于条件环境的动物可以免受损伤通常产生的缺陷。因此，海马体必须在预暴露期间形成上下文表征，随后将其存储在其他地方。一旦形成这种情境表征，就可以与无条件刺激相关联。
Hippocampal lesions in rats produce both a retrograde and an anterograde amnesia of contextual fear conditioning. The present experiments examined the anterograde deficit in context conditioning. The deficit produced by electrolytic hippocampal lesions was apparent when training occurred on 7, 14, or 28 days following surgery, confirming the durability of the amnesia. The role of the hippocampus in context conditioning may be related to an NMDA (N-methyl-D-aspartate) receptor-mediated process. Both NMDA hippocampal lesions and intrahippocampal administration of an NMDA antagonist produced anterograde amnesia. Animals preexposed to the conditioning context 28 days prior to hippocampal lesioning were protected from the deficit normally produced by the lesions. Thus, the hippocampus must form a contextual representation during preexposure that is subsequently stored elsewhere. Once formed this representation of the context can be associated with an unconditional stimulus.