Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate.
Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate.
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DOI：
10.1021/ol049439c
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发表时间：
2004-04
期刊：
影响因子：
5.2
通讯作者：
S. You;J. Kelly
中科院分区：
文献类型：
--
作者：
S. You;J. Kelly
报道了一种以二(三苯基)氧代二膦酸三氟甲磺酸为原料，由C-末端的β-氨基-α-氨基酸残基组成的二肽为原料，高效地合成咪唑啉类氨基酸的方法。这些咪唑类化合物可以很容易地转化为咪唑类化合物，并在不损失立体化学完整性的情况下与比斯特拉胺H的大内酰胺类似物结合。
A highly efficient enantiospecific synthesis of imidazoline-based amino acids is reported from dipeptides composed of a C-terminal beta-amino-alpha-amino acid residue using bis(triphenyl) oxodiphosphonium trifluoromethanesulfonate. These imidazolines were easily converted to imidazoles and incorporated into macrolactam analogues of bistratamide H without loss of stereochemical integrity.