Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment.
Placental epigenetic patterning of glucocorticoid response genes is associated with infant neurodevelopment.
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DOI：
10.2217/epi.15.28
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发表时间：
2015-08
期刊：
影响因子：
3.8
通讯作者：
Marsit CJ
中科院分区：
文献类型：
--
作者：
Paquette AG;Lester BM;Lesseur C;Armstrong DA;Guerin DJ;Appleton AA;Marsit CJ
确定NR 3C 1、HSD 11B 2、FKBP 5和ADCYAP 1 R1甲基化与新生儿神经行为结局之间的关系。在537名新生儿中，使用亚硫酸氢盐焦磷酸测序定量胎盘甲基化。通过新生儿重症监护病房网络神经行为量表得出神经行为的概况。采用探索性因素分析，甲基化因子得分和神经行为特征之间的关系进行了研究。以NR 3C 1甲基化为特征的因子得分增加与反应性、调节不良的特征相关（比值比：1.47; 95%CI：1.00-2.18），而以HSD 11B 2甲基化为特征的因子得分增加则降低了这种风险。这些结果表明，这些基因的协调调节影响神经行为，并证明了以协调的方式检查这些改变的重要性。
To determine associations between methylation of NR3C1, HSD11B2, FKBP5 and ADCYAP1R1 and newborn neurobehavioral outcomes. In 537 newborns, placental methylation was quantified using bisulfite pyrosequencing. Profiles of neurobehavior were derived via the Neonatal Intensive Care Unit Network Neurobehavioral Scales. Using exploratory factor analysis, the relationships between methylation factor scores and neurobehavioral profiles were examined. Increased scores of the factor characterized by NR3C1 methylation were associated with membership in a reactive, poorly regulated profile (odds ratio: 1.47; 95% CI: 1.00–2.18), while increased scores of the factor characterized by HSD11B2 methylation reduced this risk. These results suggest that coordinated regulation of these genes influences neurobehavior and demonstrates the importance of examining these alterations in a harmonized fashion.