Fall in Haemophilus influenzae serotype b (Hib) disease following implementation of a booster campaign
Fall in Haemophilus influenzae serotype b (Hib) disease following implementation of a booster campaign
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DOI：
10.1136/adc.2007.126888
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发表时间：
2008-08-01
影响因子：
5.2
通讯作者：
Ramsay, M. E.
中科院分区：
文献类型：
--
作者：
Ladhani, S.;Slack, M. P.;Ramsay, M. E.
目的：为了评估在1999年之后全国范围内所有年龄组的侵袭性流感嗜血杆菌血清型B（HiB）病例数量增加之后，2003年5月至9月针对6个月至4岁儿童的HiB疫苗接种加强运动的影响。设计：健康保护局感染中心前瞻性地监测英格兰和威尔士的所有流感嗜血杆菌病例，并从初级保健信托基金（PCT）在儿童计划中的疫苗覆盖率。人口：英格兰和威尔士的成人和儿童（1991年1月至2006年12月）在Hib加强运动期间，英格兰有288/303（95%）名多氯联苯疫苗接种者的疫苗覆盖率数据，显示6-12个月年龄组的覆盖率为71.8%，13- 14个月年龄组的覆盖率为63.2%。48个月年龄组。Hib加强剂运动导致加强剂目标年龄组的病例在12个月内急剧减少。在这一下降之后，报告的年龄较大的儿童和成人的病例数也有所减少。然而，自该运动以来，1至3岁儿童中报告的病例数有所增加（2004年13例，2005年26例，2006年32例），主要是年龄太小而无法在加强免疫运动中接种疫苗的儿童。这组儿童将成为2007年9月开始的学前补习计划的目标。结论：Hib助推器运动有助于在英国重新建立群体免疫力。2004年后，幼儿中Hib疾病的增加支持了在12个月大时引入Hib常规加强的决定。
Objective: To assess the impact of a Hib vaccination booster campaign targeting children aged 6 months to 4 years between May and September 2003, following a nationwide increase in the number of invasive Haemophilus influenzae serotype b (Hib) cases in all age groups after 1999.Design: The Health Protection Agency Centre for Infections prospectively monitors all cases of H influenzae disease in England and Wales and collects data from primary care trusts (PCTs) on coverage for vaccines in the childhood programme.Population: Adults and children in England and Wales (January 1991 to December 2006)Results: Data on vaccine coverage during the Hib booster campaign were available for 288/303 (95%) PCTs in England and revealed coverage of 71.8% for the 6-12-month age group and 63.2% for the 13-48-month age group. The Hib booster campaign resulted in a dramatic reduction in cases within 12 months in the age groups targeted for the booster. This decline was followed by a reduction in the number of cases reported among older children and adults. Since the campaign, however, there has been an increase in the number of cases reported among 1-3-year-old children (13 cases in 2004, 26 cases in 2005 and 32 cases in 2006), primarily in children who were too young to be vaccinated in the booster campaign. This group of children will be targeted in the pre-school catch-up programme that began in September 2007.Conclusions: The Hib booster campaign has helped to re-establish herd immunity in the UK. The increase in Hib disease among toddlers after 2004 supports the decision to introduce routine boosting for Hib at 12 months of age.