TREATMENT OF VIRULENT FOOTROT WITH LINCOMYCIN AND SPECTINOMYCIN
TREATMENT OF VIRULENT FOOTROT WITH LINCOMYCIN AND SPECTINOMYCIN
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DOI：
10.1111/j.1751-0813.1990.tb07781.x
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发表时间：
1990-07-01
影响因子：
1.1
通讯作者：
EGERTON, JR
中科院分区：
文献类型：
--
作者：
VENNING, CM;CURTIS, MA;EGERTON, JR
研究了林可霉素和大观霉素的混合物作为治疗绵羊蹄病的药物。在一项对照临床试验中，92.5%的急性和慢性毒性足腐病病例在单次肌内注射含有50 mg林可霉素和100 mg壮观霉素/ml的混合物（剂量率为1 ml/10 kg体重）后治愈。在以该剂量率连续3天给药的绵羊组中，以及在以1 ml/3.3 kg体重的剂量率给药一次的另一组中，均未观察到临床应答改善。相对于未处理对照组，3个处理组的治愈有效性分别为89%、95%和95%。在新南威尔士州西南部的2个农场，比较了林可霉素/壮观霉素与青霉素/链霉素治疗腐蹄病的疗效。治疗后14至17天进行的评估显示，在一个农场，所有122只接受林可霉素/壮观霉素治疗的母羊均已恢复，而170/175只接受青霉素-链霉素治疗的母羊在同一时期恢复。在第二个农场，林可霉素/大观霉素治疗的90只母羊中有87只恢复，而青霉素/链霉素治疗的同一羊群中190只绵羊中有184只恢复。支持性足浴似乎并不能改善两个治疗组的临床反应，并且所做的修剪仅足以确立诊断并去除过度生长的角。
A mixture of lincomycin and spectinomycin was investigated as a treatment for footrot in sheep. In a controlled clinical trial 92.5% of acute and chronic cases of virulent footrot were cured following a single intramuscular injection of a mixture containing 50 mg lincomycin and 100 mg spectinomycin/ml at a dose rate of 1 ml/10 kg bodyweight. No improvement in clinical response was observed in groups of sheep treated on 3 successive days with this dose rate nor in another group treated once at a dose rate 1 ml/3.3 kg bodyweight. Cure effectiveness of each of the 3 treatment groups relative to untreated controls was 89%, 95% and 95%. Efficacy of lincomycin/spectinomycin was compared with that of penicillin/streptomycin in the treatment of footrot on 2 farms in south western New South Wales. Assessments made 14 to 17 d after treatment showed that on one farm all 122 ewes treated with lincomycin/spectinomycin had recovered while 170 of 175 ewes treated with penicillin-streptomycin recovered in the same period. On the second farm 87 of 90 ewes treated with lincomycin/spectinomycin recovered, compared with 184 of 190 sheep in the same flock treated with penicillin/streptomycin. Supportive footbathing did not seem to improve the clinical response in either treatment group and the paring done was sufficient only to establish diagnosis and to remove grossly overgrown horn.