Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes
Deletion of macrophage migration inhibitory factor gene induces down regulation of sex hormones and ultrastructural abnormalities in mouse testes
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DOI：
10.1016/j.reprotox.2005.08.001
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Mori, C
中科院分区：
文献类型：
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作者：
Anahara, R;Toyama, Y;Mori, C
巨噬细胞移动抑制因子(MIF)是一种多功能蛋白质，具有促炎症细胞因子、垂体激素、免疫调节剂和有丝分裂原等多种功能。MIF基因敲除(MIFKO)小鼠已被用于研究皮肤损伤、脊髓损伤等多种组织的MIF反应，但对MIFKO小鼠睾丸的研究较少。这项研究报告了血清和睾丸内雌二醇和睾酮的水平，睾丸的超微结构，以及体外受精的初步发现。我们的结果显示，在MIFKO小鼠中，雌二醇和睾酮水平下降，精子发生变形。这些初步的研究结果可能有助于更好地理解MIF在小鼠睾丸中所起的作用。(C)2005 Elsevier Inc.保留所有权利。
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that acts as a pro-inflammatory cytokine, pituitary hormone, immunoregulator and mitogen. The MIF gene knockout (MIFKO) mouse has been used to study the MIF response in many tissues, such as with skin injury and spinal cord injury; however, there is little information about the MIFKO mouse testis. This study reports the levels of serum and intratesticular estradiol and testosterone, the ultrastructure of the testis, and preliminary findings from in vitro fertilization. Our results revealed a decrease in estradiol and testosterone levels and deformation in spermiogenesis, in the MIFKO mouse. These initial findings study may lead to a better understanding of the role that MIF plays in the mouse testis. (c) 2005 Elsevier Inc. All rights reserved.