Functional imaging of cognition in an old-old population: A case for portable functional near-infrared spectroscopy
Functional imaging of cognition in an old-old population: A case for portable functional near-infrared spectroscopy
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DOI：
10.1371/journal.pone.0184918
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发表时间：
2017-10-12
期刊：
影响因子：
3.7
通讯作者：
Sparto, Patrick J.
中科院分区：
文献类型：
--
作者：
Huppert, Theodore J.;Karim, Helmet;Sparto, Patrick J.
在这项研究中，功能性近红外光谱（fNIRS）被用来记录在认知测试过程中的老年人（88 +/-6岁; N = 19）生活在住宅护理社区的大脑激活。这一人群，这往往是与个人独立性的丧失，由于身体或认知能力下降与老龄化，也往往是在神经科学研究中的代表性不足，因为有限的手段参与研究，往往发生在大城市或大学中心。在这项研究中，我们证明了使用便携式8源4探测器fNIRS系统来测量参与者在住宅护理社区中心的大脑活动的可行性和初步结果。使用fNIRS，在一系列计算机化认知测试期间记录大脑信号，包括符号数字编码测试（SDC）、Stroop测试（ST）和转移注意力测试（SAT）。SDC和SAT引起了更大的活动，在左中额感兴趣的区域。ST的三个组成部分在右中额和上级额区和左上级额区产生增加。在不一致的ST期间观察到高龄和右中额区激活增加之间的关联。虽然没有参与者根据简短的便携式精神状态问卷患有临床痴呆症，但在这些认知测试中，组表现略低于年龄标准值。这些结果表明，在住宅环境中获得功能性神经影像学指标的能力，这最终可能有助于老年人痴呆症的预后和护理。
In this study, functional near-infrared spectroscopy (fNIRS) was used to record brain activation during cognitive testing in older individuals (88 +/- 6yo; N = 19) living in residential care communities. This population, which is often associated with loss of personal independence due to physical or cognitive decline associated with aging, is also often under-represented in neuroscience research because of a limited means to participate in studies which often take place in large urban or university centers. In this study, we demonstrate the feasibility and initial results using a portable 8-source by 4-detector fNIRS system to measure brain activity from participants within residential care community centers. Using fNIRS, brain signals were recorded during a series of computerized cognitive tests, including a Symbol Digit Coding test (SDC), Stroop Test (ST), and Shifting Attention Test (SAT). The SDC and SAT elicited greater activity in the left middle frontal region of interest. Three components of the ST produced increases in the right middle frontal and superior frontal, and left superior frontal regions. An association between advanced age and increased activation in the right middle frontal region was observed during the incongruent ST. Although none of the participants had clinical dementia based on the short portable mental status questionnaire, the group performance was slightly below age-normed values on these cognitive tests. These results demonstrate the capability for obtaining functional neuroimaging measures in residential settings, which ultimately may aid in prognosis and care related to dementia in older adults.