RELATIONSHIP OF B CELL ALLOANTIBODIES TO RENAL ALLOGRAFT SURVIVAL
RELATIONSHIP OF B CELL ALLOANTIBODIES TO RENAL ALLOGRAFT SURVIVAL
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B 细胞同种抗体与同种异体移植肾存活的关系
DOI：
10.1097/00007890-197904000-00014
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发表时间：
1979
期刊：
影响因子：
6.2
通讯作者：
H. Lee
中科院分区：
文献类型：
--
作者：
T. Mohanakumar;Martin A. Gidedlin;C. Rhodes;C. Duvall;G. Mendez;A. Kaplan;H. Lee
摘要 为了明确供体特异性 B 淋巴细胞同种抗体与肾同种异体移植物存活的关系，检查了移植前和移植后获得的纵向血清样品中对供体 B 淋巴细胞具有细胞毒性的抗体。 17 名同种异体肾移植受者中有 10 名在移植前和/或移植后具有针对供体 B 淋巴细胞的抗体，但没有针对 T 淋巴细胞的抗体。尽管已有 B 细胞抗体，但三名患者还是成功进行了移植；然而，7 名在移植后才产生 B 细胞抗体的人要么正在经历慢性排斥反应 (4)，要么已经出现严重的排斥反应危机 (3)。七名没有 B 细胞抗体的患者具有功能性移植物。在所有病例中，在出现排斥反应的生化和临床证据之前均检测到了 B 细胞抗体。当检查 38 名肾移植受者的血清中是否存在对一组不相关的 B 淋巴细胞具有细胞毒性的 B 细胞抗体时，也发现了类似的结果。这些结果表明，移植后 B 细胞同种抗体的产生通常与排斥相关，并且可以通过阳性 B 细胞交叉配型进行成功的肾移植。
SUMMARY To define the relationship of donor-specific B lymphocyte alloantibodies to renal allograft survival, longitudinal serum samples obtained pre- and post-transplantation were examined for antibodies cytotoxic to donor B lymphocytes. Ten of 17 renal allograft recipients had antibodies to donor B lymphocytes but not T lymphocytes either pre- and/or post-transplantation. Three patients underwent successful transplants despite preformed B cell antibodies; however, seven who developed B cell antibodies only after transplantation are either undergoing chronic rejection (4) or have had severe rejection crisis (3). Seven patients with no B cell antibodies have functioning grafts. In all cases, B cell antibodies were detected before biochemical and clinical evidence of rejection. Similar findings were noted when sera of 38 renal transplant recipients were examined for B cell antibodies cytotoxic to an unrelated panel of B lymphocytes. These results demonstrate that the development of B cell alloantibodies after transplantation is often associated with rejection and that successful renal transplantation can be performed across a positive B cell crossmatch.