Molecular mechanisms of lncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis in gastric cancer
Molecular mechanisms of lncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis in gastric cancer
复制标题
lncRNA SMARCC2/miR-551b-3p/TMPRSS4轴在胃癌中的分子机制
DOI：
10.1016/j.canlet.2018.01.032
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发表时间：
2018-04-01
期刊：
影响因子：
9.7
通讯作者：
Qiao, Liang
中科院分区：
文献类型：
--
作者：
Yuan, Hao;Chen, Zhaofeng;Qiao, Liang
miR-551 b-3 p在胃癌组织中表达降低，但其生物学作用和潜在机制尚不清楚。在这项研究中，我们发现miR-551 b-3 p的表达与肿瘤浸润深度和淋巴结转移呈负相关，但与肿瘤分化和患者生存呈正相关。miR-551 b-3 p对胃癌细胞的增殖、移动性和侵袭性有负面影响。LncRNA SMARCC 2通过与胃癌细胞中miR-551 b-3 p的mRNA反应元件结合来抑制其表达。LncRNA SMARCC 2的过表达促进胃癌细胞的增殖和迁移，而LncRNA SMARCC 2的抑制则相反。TMPRSS 4是miR-551 b-3 p的直接靶基因。结论：miR-551 b-3 p在胃癌中具有抑癌基因的功能，其功能受LncRNA SMARCC 2/miR-551 b-3 p/TMPRSS 4轴的调控。(C)2018 Elsevier B. V.版权所有。
Decreased expression of miR-551b-3p has been identified in gastric cancer tissues but its biological role and underlying mechanism in this malignancy is poorly understood. In this study, we show that the expression of miR-551b-3p negatively correlates with the depth of tumour invasion and lymphatic metastasis, but it positively correlates with tumour differentiation and the patient survival. MiR-551b-3p negatively affects the proliferation, mobility and invasiveness of gastric cancer cells. LncRNA SMARCC2 inhibits the expression of miR-551b-3p through binding to its mRNA response elements in gastric cancer cells. Overexpression of LncRNA SMARCC2 enhances the proliferation and migration of gastric cancer cells, while inhibition of LncRNA SMARCC2 does the opposite. TMPRSS4 is a direct target gene of miR-551b-3p. We conclude that miR-551b-3p functions as a tumour suppressor gene in gastric cancer, and its function is regulated by LncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis. (C) 2018 Elsevier B.V. All rights reserved.