A WORSE PROGNOSIS FOR SMOKERS WITH PROSTATE-CANCER
A WORSE PROGNOSIS FOR SMOKERS WITH PROSTATE-CANCER
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DOI：
10.1016/s0022-5347(01)67253-7
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发表时间：
1995-07-01
影响因子：
6.6
通讯作者：
DANIELL, HW
中科院分区：
文献类型：
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作者：
DANIELL, HW
为了找出可能解释吸烟者前列腺癌死亡率较高的现象，我们对社区医院的 359 名新诊断出肿瘤的患者进行了肿瘤分期和分级、宿主年龄、肥胖、吸烟习惯和生存情况的分析。在 235 名患有非 A 期肿瘤的男性中，D 期疾病与宿主吸烟独立相关（比值比 2.1，95% 置信区间 1.3 至 4.3，p = 0.015），以及较高的肿瘤等级、较年轻的宿主年龄和不肥胖。 16 名重度吸烟者中的 69%、44 名其他吸烟者中的 41% 以及非吸烟者中的 31% 存在 D 期疾病。 D2 期疾病吸烟者的 5 年肿瘤特异性死亡率高于不吸烟者（88% vs 63%，p
To identify phenomena that might explain a higher mortality-to-incidence ratio for prostate cancer among smokers, 359 patients with newly diagnosed tumors at a community hospital were analyzed by tumor stage and grade, host age, obesity, smoking habits and survival. Among the 235 men with nonstage A tumors, stage D disease was independently related to host smoking (odds ratio 2.1, 95% confidence interval 1.3 to 4.3, p = 0.015), as well as to higher tumor grade, younger host age and lack of obesity. Stage D disease was present in 69% of 16 heavy smokers, 41% of 44 other smokers and 31% of nonsmokers. The 5-year tumor-specific mortality rate was greater among smokers than nonsmokers with stage D2 disease (88% versus 63%, p