Infection resistance of degradable versus non-degradable biomaterials: An assessment of the potential mechanisms
Infection resistance of degradable versus non-degradable biomaterials: An assessment of the potential mechanisms
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DOI：
10.1016/j.biomaterials.2013.07.044
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发表时间：
2013-11-01
期刊：
影响因子：
14
通讯作者：
Rochford, Edward T. J.
中科院分区：
文献类型：
--
作者：
Daghighi, Seyedmojtaba;Sjollema, Jelmer;Rochford, Edward T. J.
预期寿命的延长和医学的发展已经导致越来越依赖于生物材料植入物和装置来支持或恢复人体解剖结构和功能。然而，植入生物材料的存在导致感染易感性增加。由于生物材料相关感染的潜在结局的严重性，已采用不同的策略来降低感染风险。有趣的是，与不可降解的合成生物材料相比，可降解的生物材料表现出对细菌感染的抵抗力增加。目前关于可降解生物材料如何增强抗感染能力的具体机制的知识是有限的。因此，在本文中，参考目前的知识水平，对一些解释与使用可降解生物材料相比不可降解生物材料相关的感染风险降低的假设进行了评价和讨论。(c)2013爱思唯尔有限公司保留所有权利。
Extended life expectancy and medical development has led to an increased reliance on biomaterial implants and devices to support or restore human anatomy and function. However, the presence of an implanted biomaterial results in an increased susceptibility to infection. Due to the severity of the potential outcomes of biomaterial-associated infection, different strategies have been employed to reduce the infection risk. Interestingly, degradable biological materials demonstrate increased resistance to bacterial infection compared to non-degradable synthetic biomaterials. Current knowledge about the specific mechanisms of how degradable biological materials are afforded increased resistance to infection is limited. Therefore, in this paper a number of hypotheses to explain the decreased infection risk associated with the use of degradable versus non-degradable biomaterials are evaluated and discussed with reference to the present state of knowledge. (c) 2013 Elsevier Ltd. All rights reserved.