Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards.
Linking scientific discovery and better health for the nation: the first three years of the NIH's Clinical and Translational Science Awards.
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DOI：
10.1097/acm.0b013e3181ccb74d
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发表时间：
2010-03
期刊：
影响因子：
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通讯作者：
Principal Investigators of National Institutes of Health Clinical and Translational Science Awards
中科院分区：
文献类型：
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作者：
Califf RM;Berglund L;Principal Investigators of National Institutes of Health Clinical and Translational Science Awards
一个将基础生物医学研究转化为有用和有效实施的临床诊断、预防和治疗实践的综合系统对国家健康至关重要。然而，美国的临床和转化研究（CTR）的状况被描述为分散、缓慢、昂贵和协调性差。作为其路线图计划的一部分，美国国立卫生研究院设立了临床和转化科学奖（CTSA），这是一项雄心勃勃的计划，旨在通过加速将科学发现转化为有用的疗法，然后开发方法以确保这些疗法到达最需要它们的患者，从而改变美国生物医学研究的行为。作者回顾了导致创建CTSA的美国生物医学研究企业的情况，并讨论了CTSA的最初战略计划，该计划是根据该计划前3年的经验制定的，旨在克服研究机构内部和之间的组织，方法和文化障碍。作者还描述了在这些努力中遇到的挑战，并讨论了这一重要的国家卫生保健计划的承诺，这对于为进行研究所需的科学劳动力创建一个管道至关重要，这反过来又为改善美国的健康提供了合理的证据基础。
A comprehensive system for translating basic biomedical research into useful and effectively implemented clinical diagnostic, preventive, and therapeutic practices is essential to the nation’s health. The state of clinical and translational research (CTR) in the United States, however, has been characterized as fragmented, slow, expensive, and poorly coordinated. As part of its Roadmap Initiative, the National Institutes of Health instituted the Clinical and Translational Science Awards (CTSA), a sweeping and ambitious program designed to transform the conduct of biomedical research in the United States by speeding the translation of scientific discoveries into useful therapies and then developing methods to ensure that those therapies reach the patients who need them the most. The authors review the circumstances of the U.S. biomedical research enterprise that led to the creation of the CTSA and discuss the initial strategic plan of the CTSA, which was developed from the first 3 years of experience with the program and was designed to overcome organizational, methodological, and cultural barriers within and among research institutions. The authors also describe the challenges encountered during these efforts and discuss the promise of this vital national health care initiative, which is essential to creating a pipeline for the scientific workforce needed to conduct research that will in turn provide a rational evidence base for better health in the United States.