A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of RAD52-L89F to interact with RAD59
A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of RAD52-L89F to interact with RAD59
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DOI：
10.1534/genetics.104.030551
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发表时间：
2004-09-01
期刊：
影响因子：
3.3
通讯作者：
Aguilera, A
中科院分区：
文献类型：
--
作者：
Cortés-Ledesma, F;Malagón, F;Aguilera, A
我们分离了一种新的rad 52突变，rad 152-L 89 F，它特异性地损害rad 51 Delta细胞中的重组。rad 52-L 89 F显示与rad 59 Delta相似的表型，并编码与Rad 59相互作用能力受损的突变蛋白。这些结果支持Rad 59通过与Rad 52的物理相互作用在同源重组中起作用的想法。
We isolated a novel rad52 Mutation, rad152-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52.