Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
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DOI：
10.1016/s0002-9149(03)00533-2
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发表时间：
2003-07-15
影响因子：
2.8
通讯作者：
Li, YY
中科院分区：
文献类型：
--
作者：
Zeng, XH;Zeng, XJ;Li, YY
本研究旨在评价黄连素治疗慢性充血性心力衰竭（CHF）的有效性和安全性。五十六例CHF患者24小时Halter监测室性早搏（VPC）和/或非持续性室性心动过速（VT）>90例，随机分为两组。所有患者均接受常规CHF治疗，包括血管紧张素转换酶抑制剂、地高辛、利尿剂和硝酸酯类药物。治疗组79例同时给予黄连素1.2 ~ 2.0g/d。其余77名患者服用安慰剂。在治疗8周后和平均24个月的随访期间，对症状、6分钟步行试验、左心室（LV）射血分数（EF）、VPC的频率和复杂性以及生活质量进行了评估。小檗碱治疗后，与对照组相比，LVEF、运动能力、呼吸困难-疲劳指数的改善以及VPC的频率和复杂性的降低均显著增加。在长期随访中，黄连素治疗组患者的死亡率显著降低（7例接受治疗的患者死亡，13例接受安慰剂治疗的患者死亡，P
This study was designed to assess the efficacy and safety of berberine for chronic congestive heart failure (CHF). One hundred fifty-six patients with CHF and >90 ventricular premature complexes (VPCs) and/or nonsustained ventricular tachycardia (VT) on 24-hour Halter monitoring were randomly divided into 2 groups. All patients were given conventional therapy for CHF, consisting of angiotensin-converting enzyme inhibitors, digoxin, diuretics, and nitrates. Patients in the treatment group (n = 79) were also given berberine 1.2 to 2.0 g/day. The remaining 77 patients were given placebo. Symptoms, a 6-minute walk test, left ventricular (LV) ejection fraction (EF), frequency and complexity of VPCs, and quality,of life were assessed after 8 weeks of treatment and during a mean 24-month follow-up. After treatment with berberine, there was a significantly greater increase in LVEF, exercise capacity, improvement of the dyspnea-fatigue index, and a decrease of frequency and complexity of VPCs compared with the control group. There was a significant decrease in mortality in the berberine-treated patients during long-term follow-up (7 patients receiving treatment died vs 13 on placebo, p