A comparison of clustering solutions for cognitive heterogeneity in schizophrenia
A comparison of clustering solutions for cognitive heterogeneity in schizophrenia
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DOI：
10.1017/s1355617798003531
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发表时间：
1998-07-01
影响因子：
2.6
通讯作者：
Seaton, BE
中科院分区：
文献类型：
--
作者：
Goldstein, G;Allen, DN;Seaton, BE
利用221名精神分裂症患者的样本，将基于一系列测试的聚类分析解决方案与基于韦氏智力量表子测试的解决方案进行比较，这些测试包括霍尔斯特德类别和触觉表现测试、轨迹制造测试和威斯康星卡片分类测试。两种分析都允许四集群解决方案，我们发现解决方案之间存在微弱但显著的关联。对两种溶液的外部效度的检验显示，基于韦氏量表的溶液与临床变量有更强的关联。主要结论是，精神分裂症的认知异质性存在于广泛的能力范围内，并且似乎反映了能力水平的连续性和可能存在的亚型的结合，需要进一步的神经心理学和神经生物学验证。
A cluster analytic solution based upon a battery of tests consisting of the Halstead Category and Tactual Performance Tests, the Trail Making Test, and the Wisconsin Card Sorting Test was compared with a solution based on the subtests of the Wechsler intelligence scales, utilizing a sample of 221 schizophrenic patients. Both analyses permitted four-cluster solutions, and we found a weak but significant degree of association between solutions. Examination of external validity of the two solutions revealed stronger associations with clinical variables for the Wechsler-scale-based solution. The major conclusions were that the existence of cognitive heterogeneity in schizophrenia exists across a broad range of abilities, and appears to reflect a combination of continuity of ability level and existence of possible subtypes requiring further neuropsychological and neurobiological verification.