Topological Considerations in Biomolecular Condensation.
Topological Considerations in Biomolecular Condensation.
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DOI：
10.3390/biom13010151
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发表时间：
2023-01-11
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
生物分子凝聚和相分离越来越多地被理解为在细胞区室化和涉及功能和病理的细胞机器的时空调节中起关键作用。当前研究的一个关键方面是深入了解这些过程的潜在物理机制。因此，软物质和聚合物物理学，混合热力学和材料科学的概念已被用于理解多价大分子的凝聚机制，导致粘弹性介观超分子组装。在这里，我们专注于两个拓扑概念，最近一直提供关键的机械理解领域。首先，我们将讨论如何渗透提供了一个网络拓扑相关的框架，提供了一个有趣的范例，以了解密集的“连接”凝聚结构的复杂网络，因此，他们的相行为。其次，我们将讨论纠缠的想法，作为另一个拓扑概念，有深刻的根源，在聚合物物理和生物分子凝聚体的重要影响。我们将首先回顾这些概念的一些历史发展和基本原理，然后讨论当前的进展和最近的例子。我们的讨论以一些开放性问题和解决这些问题的挑战结束，暗示着揭示修改现有知识的新可能性以及与凝聚态科学相关的新概念的发展。
Biomolecular condensation and phase separation are increasingly understood to play crucial roles in cellular compartmentalization and spatiotemporal regulation of cell machinery implicated in function and pathology. A key aspect of current research is to gain insight into the underlying physical mechanisms of these processes. Accordingly, concepts of soft matter and polymer physics, the thermodynamics of mixing, and material science have been utilized for understanding condensation mechanisms of multivalent macromolecules resulting in viscoelastic mesoscopic supramolecular assemblies. Here, we focus on two topological concepts that have recently been providing key mechanistic understanding in the field. First, we will discuss how percolation provides a network-topology-related framework that offers an interesting paradigm to understand the complex networking of dense ‘connected’ condensate structures and, therefore, their phase behavior. Second, we will discuss the idea of entanglement as another topological concept that has deep roots in polymer physics and important implications for biomolecular condensates. We will first review some historical developments and fundamentals of these concepts, then we will discuss current advancements and recent examples. Our discussion ends with a few open questions and the challenges to address them, hinting at unveiling fresh possibilities for the modification of existing knowledge as well as the development of new concepts relevant to condensate science.
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影响因子：
4.3
作者：
Bueno, Carlos;Liman, James;Schafer, Nicholas;Cheung, Margaret;Wolynes, Peter
通讯作者：
Wolynes, Peter
影响因子：
5.5
作者：
BAXANDALL, LG
通讯作者：
BAXANDALL, LG
DOI：
10.1073/pnas.2210177119
发表时间：
2022-08-09
影响因子：
11.1
作者：
通讯作者：
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影响因子：
4.4
作者：
DEGENNES, PG
通讯作者：
DEGENNES, PG
影响因子：
4.3
作者：
Choi, Jeong-Mo;Dar, Furqan;Pappu, Rohit, V
通讯作者：
Pappu, Rohit, V