The neural representation of sensorimotor transformations in a human perceptual decision making network
The neural representation of sensorimotor transformations in a human perceptual decision making network
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DOI：
10.1016/j.neuroimage.2013.04.085
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发表时间：
2013-10-01
期刊：
影响因子：
5.7
通讯作者：
Kayser, Andrew S.
中科院分区：
文献类型：
--
作者：
Erickson, Drew T.;Kayser, Andrew S.
人类可以快速使用神经网络将复杂的视觉刺激转化为运动反应。在这个网络中的一个关键区域，顶内沟（IPS）的活动，已与证据积累和运动规划，从而牵连它在感觉运动的转换。如果这样的转换发生在大脑区域内，一个关键的和未经检验的预测是，神经活动反映了可用的证据和运动规划的时间可以独立操纵的参数量。为了研究这些想法，我们构建了一个点运动辨别任务，其中关于响应模态（使用什么）和响应映射（如何使用它）的信息在呈现点运动相干性刺激之前或之后独立提供，该刺激的强度在试验中各不相同。与我们的假设相一致，IPS内的活动与点运动的连贯性在刺激阶段，并作为必要的响应信息被延迟，IPS活动的峰值转移到响应阶段。相反，运动敏感区MT+和辅助运动区等区域分别表现出仅限于任务的刺激和反应阶段的活动。这些结果表明，在IFS的活动与时间上可分离的表示与证据积累和运动规划相一致，并建议IPS是感知决策网络内的感觉运动转换的核心组成部分。(c)2013 Elsevier Inc. All rights reserved.
Humans can quickly engage a neural network to transform complex visual stimuli into a motor response. Activity from a key region within this network, the intraparietal sulcus (IPS), has been associated with evidence accumulation and motor planning, thus implicating it in sensorimotor transformations. If such transformations occur within a brain region, a key and untested prediction is that neural activity reflecting both the parametric amount of evidence available and the timing of motor planning can be independently manipulated. To investigate these ideas, we constructed a dot motion discrimination task in which information about response modality (what to use) and response mapping (how to use it) was provided independently either before or after presentation of a dot motion coherence stimulus whose strength varied across trials. Consistent with our hypothesis, activity within IPS covaried with dot motion coherence during the stimulus phase, and as information necessary for the response was delayed, the peak of IPS activity shifted to the response phase. In contrast, areas such as the motion-sensitive region MT+ and the supplementary motor area demonstrated activity limited to the stimulus and response phases of the task, respectively. These results show that activity in IFS correlates with temporally dissociable representations consistent with both evidence accumulation and motor planning, and suggest that IPS is a core component for sensorimotor transformations within the perceptual decision-making network. (c) 2013 Elsevier Inc. All rights reserved.