Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis
Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis
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DOI：
10.1016/j.clinbiochem.2010.07.007
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发表时间：
2010-09-01
影响因子：
2.8
通讯作者：
Honsawek, Sittisak
中科院分区：
文献类型：
--
作者：
Chayanupatkul, Maneerat;Honsawek, Sittisak
目的：检测膝关节骨性关节炎(OA)患者血浆和滑液中可溶性晚期糖基化终产物受体(SRAGE)水平，并探讨其与疾病严重程度的关系。设计与方法：36例膝骨性关节炎患者和15例健康对照。按Kellgren-Lawrence分类进行OA分级。结果：OA患者血浆sRAGE水平明显低于正常对照组(P=0.01)。血浆sRAGE水平显著高于配对的滑液(P=0.001)。血浆和滑液中sRAGE浓度与病情严重程度呈显著负相关(分别为r=-0.65，P<0.001和r=-0.55，P=0.001)。进一步分析显示，血浆和滑液中的sRAGE浓度呈显著正相关(r=0.81，P&0.001)。结论：骨性关节炎患者的sRAGE水平明显低于正常对照组，且随着病情的加重，血浆和滑液中的sRAGE水平也显著降低。因此，SRAGE水平可作为评估膝骨性关节炎严重程度和进展的生化标志物。(C)2010年加拿大临床化学家协会。爱思唯尔公司出版，版权所有。
Objectives: The aim of this study was to measure soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid of knee osteoarthritis (OA) patients and to determine the correlation between sRAGE levels and disease severity.Design and methods: Thirty-six OA patients and 15 healthy controls were enrolled in this study. OA grading was performed using the Kellgren-Lawrence classification. sRAGE levels in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay.Results: Plasma sRAGE levels were significantly lower in OA patients than in healthy controls (P = 0.01). sRAGE levels in plasma were remarkably higher with regard to paired synovial fluid (P = 0.001). Additionally, sRAGE concentrations in plasma and synovial fluid showed significant inverse correlation with disease severity (r = -0.65, P < 0.001 and r = -0.55, P = 0.001, respectively). Further analysis showed that there was a strong positive correlation between plasma and synovial sRAGE concentration (r = 0.81, P < 0.001).Conclusions: sRAGE levels were significantly lower in OA patients compared with controls, and sRAGE levels in plasma and synovial fluid also decreased significantly as the disease severity increased. Accordingly, sRAGE levels could be used as a biochemical marker for assessing the severity and progression of knee OA. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.