High-normal blood pressure and cognition: supplying the missing data.
High-normal blood pressure and cognition: supplying the missing data.
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正常高血压和认知：提供缺失的数据。
DOI：
10.1161/hypertensionaha.108.114165
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Robbins,MichaelA
中科院分区：
文献类型：
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作者：
Elias,MerrillF;Elias,PenelopeK;Dore,GregoryA;Robbins,MichaelA
在2008年3月的《高血压》杂志中，Knecht等人1报道了正常高血压与认知能力差有关。根据样本（N377;平均年龄：64岁）的平均收缩压（BP; SBP）值绘制总体认知能力指标的预测平均值，该样本定义为以下类别：120、120 - 130、130 - 140、140 - 150、150 - 160、160 - 170和170 mm Hg。认知能力从最低血压组下降到160至170 mmHg。SBP和认知之间的这种逆线性关系先前已经描述过。2-4 Knecht等人1指出，SBP和认知之间的反比关系通过了BP值的参考范围（图2），但他们在仅限于收缩压和舒张压参考范围内的人群的分析中没有将SBP与认知能力联系起来，这些分析是更精确地估计正常BP范围内人群认知能力下降所必需的。Knecht等1在一次检查中同时测量SBP和认知，他们指出了这一局限性。虽然获得了几个领域的认知表现的数据，结果只报告了一个全球综合评分。使用缅因州-锡拉丘兹纵向研究的数据，我们进行了上述每一项缺失分析。这些分析为Knecht等人的发现提供了重要的额外支持。缅因州-锡拉丘兹纵向研究于1975年启动，涉及6波基于社区样本的BP和BP相关风险因素的数据收集。3-5在我们的分析中，我们将从第1波到第6波的所有可用SBP测量值的平均值（每波15个测量值）与一组扩展的认知性能测量值相关联，
In the March 2008 issue of Hypertension, Knecht et al1 report that high-normal blood pressure is associated with poor cognitive performance. Predicted means of a global cognitive performance measure were plotted against mean systolic blood pressure (BP; SBP) values for a sample (N377; mean age: 64 years) defined by the following categories: 120, 120 to 130, 130 to 140, 140 to 150, 150 to 160, 160 to 170, and 170 mm Hg. Cognitive performance decreased from the lowest BP grouping to 160 to 170 mmHg. This inverse linear relation between SBP and cognition has been described previously. 2–4 Knecht et al1 note that the inverse relation between SBP and cognition passes through the reference range of BP values (Figure 2), but they did not relate SBP to cognitive performance in analyses limited to only those persons within the reference range of systolic and diastolic BP values, analyses that are necessary to more precisely estimate the decrement in cognitive performance for persons within the normal BP range. Knecht et al1 measured SBP and cognition concurrently at a single examination, a limitation that they note. Although data on several domains of cognitive performance were obtained, findings were reported only for a global composite score. Using data from the Maine-Syracuse Longitudinal Study, we performed each of the missing analyses noted above. These analyses provide important additional support for the Knecht et al1 finding.Initiated in 1975, the Maine-Syracuse Longitudinal Study involves 6 waves of data collection on BP and BP-related risk factors in a community-based sample. 3–5 In our analysis, we relate the average of all of the available SBP measurements from wave 1 through wave 6 (15 measurements per wave) to an expanded set of cognitive performance measures introduced at