C-reactive protein in ischemic stroke - An independent prognostic factor
C-reactive protein in ischemic stroke - An independent prognostic factor
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DOI：
10.1161/01.str.32.4.917
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发表时间：
2001-04-01
期刊：
影响因子：
8.3
通讯作者：
Bocola, V
中科院分区：
文献类型：
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作者：
Di Napoli, M;Papa, F;Bocola, V
背景和目的：越来越多的证据表明c反应蛋白（CRP）在缺血性卒中预后中的重要性。然而，CRP在脑卒中后不同阶段的独立价值尚未确立。因此，我们评估了CRP在缺血性脑卒中中的预后价值。我们还比较了入院和出院时CRP与1年预后的关系。方法：193例患者纳入衍生集（n = 128）和验证集（n = 65）。在缺血性脑卒中后24小时内、48 ~ 72小时内和出院时测定血清CRP。我们研究了脑卒中后不同阶段CRP水平与预后之间的关系。我们使用多变量Cox比例风险模型调整了可能的混杂效应。结果：根据受试者操作曲线，出院时CRP的临界值为1.5 mg/dL提供了对不良后果的最佳敏感性和特异性。入院时CRP（危险比[HR] 2.78, 95% CI 1.45 ~ 5.33； P=0.0021）和出院时CRP(危险比[HR] 9.42, 95% CI 4.27 ~ 19.05
Background and Purpose-There is,growing evidence of the prognostic importance of C-reactive protein (CRP) in ischemic stroke. However, the independent value of CRP at different stages after stroke has not been established. Therefore, we assessed the prognostic values of CRP in ischemic stroke. We also compared the relation of CRP at admission and discharge with 1-year outcome.Methods-One hundred ninety-three patients were included in a derivation set (n = 128) and a validation set (n = 65). Serum CRP was measured, within 24 hours after index ischemic stroke, within 48 to 72 hours, and at hospital discharge. We examined the association between the level of CRP at different stages after stroke and outcome. We adjusted for the possible confounding effect using a multivariate Cox proportional hazard model.Results-A cutoff point of 1.5 mg/dL for CRP at discharge provided optimum sensitivity and specificity for adverse outcome, based on the receiver operator curves. CRP at admission (hazard ratio [HR] 2.78, 95% CI 1.45 to 5.33; P=0.0021) and discharge (HR 9.42, 95% CI 4.27 to 19.05; P