Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice.
Vagus nerve is involved in the changes in body temperature induced by intragastric administration of 1,8-cineole via TRPM8 in mice.
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迷走神经参与通过 TRPM8 给小鼠灌胃 1,8-桉树脑引起的体温变化。
DOI：
10.1016/j.neulet.2017.04.018
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发表时间：
2017
影响因子：
2.5
通讯作者：
Tsutomu Fukuwatari
中科院分区：
文献类型：
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作者：
Tomomi Urata;Noriyuki Mori;Tsutomu Fukuwatari
瞬时受体电位Melastatin 8（TRPM 8）是由轻度寒冷温度（<28 °C）激活的冷受体。TRPM 8在皮肤感觉神经中表达，参与冷感觉和温度调节。TRPM 8 mRNA在各种组织中检测到，包括胃肠道粘膜和迷走传入神经。迷走传入神经特异性TRPM 8表达与体温调节之间的关系尚不清楚。在这项研究中，我们的目的是调查是否TRPM 8在迷走传入神经的表达参与自主体温调节。我们发现，灌胃给予TRPM 8激动剂1，8-桉叶素可增加肩胛内棕色脂肪组织和结肠温度，而M8-B治疗（TRPM 8拮抗剂）可抑制这些反应。静脉注射1，8-桉叶素也显示类似的效果。在切断迷走神经的小鼠中，灌胃给予1，8-桉叶素所诱导的反应被减弱。这些结果表明，TRPM 8在皮肤感觉神经以外的组织中表达，参与自主体温调节反应。
Transient Receptor Potential Melastatin 8 (TRPM8) is a cold receptor activated by mild cold temperature (<28 °C). TRPM8 expressed in cutaneous sensory nerves is involved in cold sensation and thermoregulation. TRPM8 mRNA is detected in various tissues, including the gastrointestinal mucosa, and in the vagal afferent nerve. The relationship between vagal afferent nerve-specific expression of TRPM8 and thermoregulation remains unclear. In this study, we aimed to investigate whether TRPM8 expression in the vagal afferent nerve is involved in autonomic thermoregulation. We found that intragastric administration of 1,8-cineole, a TRPM8 agonist, increased intrascapular brown adipose tissue and colonic temperatures, and M8-B-treatment (TRPM8 antagonist) inhibited these responses. Intravenous administration of 1,8-cineole also showed similar effects. In vagotomized mice, the responses induced by intragastric administration of 1,8-cineole were attenuated. These results suggest that TRPM8 expressed in tissues apart from cutaneous sensory nerves are involved in autonomic thermoregulation response.