Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites
Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites
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DOI：
10.1086/428137
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发表时间：
2005-03-15
影响因子：
6.4
通讯作者：
Smith, JD
中科院分区：
文献类型：
--
作者：
Gamain, B;Trimnell, AR;Smith, JD
妊娠期疟疾是一种严重的并发症，与寄生在胎盘中的红细胞（PE）隔离有关。最近的工作表明，var基因可能发挥重要作用，PE结合硫酸软骨素A（CSA），一个主要的胎盘粘附受体。在这里，我们证实，var2CSA是转录上调CSA结合寄生虫和定义CSA结合域var2CSA。var2CSA中多个结合结构域的鉴定加强了其参与妊娠期疟疾的证据，并可能应用于开发妊娠期疟疾疫苗。
Malaria in pregnancy is a serious complication associated with parasitized erythrocyte (PE) sequestration in the placenta. Recent work suggests that var genes could play an important role in PE binding to chondroitin sulfate A (CSA), a primary placental adherence receptor. Here, we confirm that var2CSA is transcriptionally up-regulated in CSA-binding parasites and define CSA-binding domains in var2CSA. The identification of multiple binding domains in var2CSA strengthens the evidence for their involvement in malaria during pregnancy and may have applications for the development of a vaccine against malaria in pregnancy.