Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations
Fabrication of Muco-Adhesive Oral Films by the 3D Printing of Hydroxypropyl Methylcellulose-Based Catechin-Loaded Formulations
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DOI：
10.1248/bpb.b19-00481
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发表时间：
2019-11-01
影响因子：
2
通讯作者：
Ozeki, Tetsuya
中科院分区：
文献类型：
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作者：
Tagami, Tatsuaki;Yoshimura, Natsumi;Ozeki, Tetsuya
随着美国食品和药物管理局批准3D打印片剂，三维（3D）打印技术的制药应用正在增加。半固体挤出型3D打印机用于3D打印水凝胶和糊状材料。我们之前开发了用于半固体挤出型3D生物打印机的片剂配方。在本研究中，我们将我们的研究扩展到粘膜粘附口腔膜制剂的制备，以3D生物打印口腔溃疡药物。我们专注于基于羟丙基甲基纤维素（HPMC）的儿茶素（模型药物）负载的水凝胶制剂，并发现水凝胶制剂的粘度取决于HPMC浓度，并且粘度对于容易的3D打印很重要。使用两种不同的干燥方法（空气干燥和冷冻干燥）制备基于HPMC的膜。膜表现出不同的药物溶出曲线，并且增加膜中HPMC的量延迟药物溶出。不同形状的基于HPMC的儿茶素负载膜的制造提供了个体化的、按需的药物的模型。我们的研究结果支持3D生物打印机（半固体挤出型3D打印机）用于制备薄膜配方的灵活应用。
Pharmaceutical applications of three dimensional (3D) printing technology are increasing following the approval of 3D-printed tablets by the U.S. Food and Drug Administration. Semi-solid extrusion-type 3D printers are used to 3D print hydrogel- and paste-based materials. We previously developed tablet formulations for semi-solid extrusion-type 3D bioprinters. In the present study, we extended our study to the preparation of muco-adhesive oral film formulations to 3D bioprint mouth ulcer pharmaceuticals. We focused on hydroxypropyl methylcellulose (HPMC)-based catechin (model drug)-loaded hydrogel formulations and found that the viscosity of a hydrogel formulation is dependent on the HPMC concentration, and that viscosity is important for facile 3D printing. HPMC-based films were prepared using two different drying methods (air drying and freeze drying). The films exhibited different drug dissolution profiles, and increasing the amount of HPMC in the film delayed drug dissolution. The fabrication of HPMC-based catechin-loaded films with different shapes provides a model of individualized, on-demand pharmaceuticals. Our results support the flexible application of 3D bioprinters (semi-solid extrusion-type 3D printers) for preparing film formulations.