The effects of prostaglandin analogues on the blood aqueous barrier and corneal thickness of phakic patients with primary open-angle glaucoma and ocular hypertension
The effects of prostaglandin analogues on the blood aqueous barrier and corneal thickness of phakic patients with primary open-angle glaucoma and ocular hypertension
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DOI：
10.1038/sj.eye.6702542
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发表时间：
2008-02-01
期刊：
影响因子：
3.9
通讯作者：
Costa, V. P.
中科院分区：
文献类型：
--
作者：
Arcieri, E. S.;Pierre Filho, P. T. P.;Costa, V. P.
目的：评价局部应用拉坦前列素、曲伏前列素和比马前列素对原发性开角型青光眼（POAG）和高眼压症（OHT）患者血-房水屏障和中央角膜厚度（CCT）的影响。设计：前瞻性、随机、设盲、交叉临床试验。方法：共有34例有晶状体眼的POAG或OHT患者完成了这项研究，这些患者既往无眼内手术或葡萄膜炎病史。患者随机接受拉坦前列素0.005%、曲伏前列素0.004%或比马前列素0.03%每日一次（2000小时）治疗1个月，随后每种药物之间有4周的洗脱期。用激光闪光计测量房水闪光。CCT计算为使用超声测厚法的五次测量的平均值。所有测量均由设盲的观察者进行（1000 h）。结果：各组之间的基线平均IOP、平均CCT和平均耀斑值之间无统计学显著差异。所有组的平均闪光值与基线相比均无统计学显著性增加（P>0.05）。各组之间的平均闪光值无统计学显著差异（P>0.05）。所有药物均显著降低了基线的平均IOP（P
Purpose: To evaluate the effects of topical latanoprost, travoprost, and bimatoprost on the blood-aqueous barrier and central corneal thickness (CCT) of patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). Design: Prospective, randomized, masked-observer, crossover clinical trial. Methods: A total of 34 phakic patients with POAG or OHT with no previous history of intraocular surgery or uveitis completed the study. Patients were randomized to use latanoprost 0.005%, travoprost 0.004%, or bimatoprost 0.03% once daily (2000 hours) for 1 month, followed by a washout period of 4 weeks between each drug. Aqueous flare was measured with a laser flare metre. CCT was calculated as the average of five measurements using ultrasound pachymetry. All measurements were performed by a masked observer (1000 h). Results: There were no statistically significant differences between baseline mean IOP, mean CCT, and mean flare values among the groups. There was no statistically significant increase in mean flare values from baseline in all groups (P>0.05). There were no statistically significant differences between mean flare values among the groups (P>0.05). All medications significantly reduced the mean IOP from baseline (P