Circadian activity rhythm in Parkinson's disease: findings from the PHASE study
Circadian activity rhythm in Parkinson's disease: findings from the PHASE study
复制标题
DOI：
10.1016/j.sleep.2021.06.023
复制
发表时间：
2021-07-12
期刊：
影响因子：
4.8
通讯作者：
Kataoka, Hiroshi
中科院分区：
文献类型：
--
作者：
Obayashi, Kenji;Saeki, Keigo;Kataoka, Hiroshi
目的：帕金森病（PD）的昼夜节律中断的特点是幅度降低，而不是相移;然而，大规模的研究评估PD患者和非PD老年人之间的昼夜节律尚未进行。本研究旨在比较PD患者和非PD老年人的昼夜活动节律（CAR）。研究方法：在对157名PD门诊患者和1111名社区老年人（对照组）进行的这项横断面研究中，使用体动计测量PD患者6天内和非PD老年人2天内的身体活动，每次间隔1分钟。数据以10为底进行对数转换，并回归到S形转换的余弦曲线。结果如下：对照组（n = 1111）的平均振幅（对数计数/min）和峰值相位分别为1.85（SD，0.52）和14：19（SD，1：15）;早期（Hoehn-Yahr I和II）PD患者（n = 95）的平均振幅（对数计数/min）和峰值相位分别为1.42（0.48）和14：24（1：20）;晚期（Hoehn-Yahr III-V）PD患者（n = 62）的平均振幅（对数计数/min）和峰值相位分别为1.23（0.54）和13：41（1：56）。多变量分析显示，早期和晚期PD组的振幅显着低于对照组。晚期PD组的顶相较对照组明显提前。随着PD分期的进展，波幅和峰值显著降低，谷值增加，峰值和主动偏移提前，稳健性减弱。结论：与非PD老年人相比，PD患者的CAR表现出相位提前，沿着振幅降低。随着PD的晚期，CAR中的相位提前也发生，沿着振幅减小和鲁棒性减弱。(c)2021爱思唯尔有限公司版权所有。
Objective: Circadian disruptions in Parkinson's disease (PD) are characterized as amplitude reduction rather than as phase shift; however, large-scale studies evaluating circadian rhythms between PD patients and non-PD older adults have not been performed. The present study aimed to compare the circadian activity rhythm (CAR) between PD patients and non-PD older adults. Methods: In this cross-sectional study on 157 PD outpatients and 1111 community-dwelling older adults (controls), physical activity was measured using actigraphy at 1-min intervals over 6 days in PD patients and 2 days in non-PD older adults. Data were base-10 log-transformed and regretted to the sigmoidally transformed cosine curve. Results: The mean amplitude (log counts/min) and acrophase were 1.85 (SD, 0.52) and 14:19 (SD, 1:15), respectively, in the controls (n = 1111); 1.42 (0.48) and 14:24 (1:20), respectively, in the early-stage (Hoehn-Yahr I and II) PD patients (n = 95); and 1.23 (0.54) and 13:41 (1:56), respectively, in the late stage (Hoehn-Yahr III-V) PD patients (n = 62). Multivariable analysis revealed significantly lower amplitude in the early-stage and late-stage PD groups than in the controls. The acrophase significantly advanced in the late-stage PD group than in the controls. With the advancement of PD stage, amplitude and peak significantly decreased; trough increased; acrophase and active offset advanced; and robustness weakened. Conclusions: Compared with non-PD older adults, PD patients exhibited a phase advance in CAR, along with amplitude reduction. With an advanced stage of PD, a phase advance in CAR also occurred, along with amplitude reduction and weakened robustness. (c) 2021 Elsevier B.V. All rights reserved.