4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides
4-(Isoxazol-3-yl)pyrimidines from Pyrimidinyl Nitrile Oxides
复制标题
DOI：
10.1055/s-0028-1087346
复制
发表时间：
2008-12-01
期刊：
影响因子：
2
通讯作者：
Kurth, Mark J.
中科院分区：
文献类型：
--
作者：
Choung, Wonken;Lorsbach, Beth A.;Kurth, Mark J.
The 1,3-dipolar cycloaddition reaction of pyrimidinyl aldoxime derived nitrile oxides and alkynes delivers 4-(isoxazol-3-yl)pyrimidines. The procedures reported accommodate three points of diversification around this bisheterocyclic scaffold and the resulting library of compounds has been added to the National Institutes of Health repository (ca. 10 mg of each with >90% purity) for pilot-scale biomedical studies with bioassay data available at the National Center for Biotechnology Information PubChem database.
