Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring
Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring
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DOI：
10.1002/adfm.201700232
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发表时间：
2018-03-21
影响因子：
19
通讯作者：
Dayeh, Shadi A.
中科院分区：
文献类型：
--
作者：
Ganji, Mehran;Kaestner, Erik;Dayeh, Shadi A.
记录神经外科干预期间的神经活动对于改善患者预后和促进我们对神经机制和组织的理解都是一个宝贵的工具。然而，提高临床电极的信噪比和空间特异性需要克服由于金属电化学界面属性受损而造成的大量物理障碍。基于poly(3，4-ethylenedioxythiophene)：poly(styrenesulfonate)(PEDOT：PSS)的界面的电化学性质超过了目前临床上使用的皮层脑电电极。在这里，PEDOT：PSS微电极阵列的可靠制造工艺被证明用于安全和高保真的术中人脑监测。PEDOT：PSS微电极在各种临床相关条件下测量显著的差动神经调制。这项研究报告了第一个诱发的(刺激锁定的)认知活动，其幅度跨软膜表面距离的变化小至400微米，潜在地使基础神经生理学研究能够在神经微电路的规模上进行。
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal-to-noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those of current clinical electrocorticography electrodes. Here, robust fabrication process of PEDOT:PSS microelectrode arrays is demonstrated for safe and high fidelity intraoperative monitoring of human brain. PEDOT:PSS microelectrodes measure significant differential neural modulation under various clinically relevant conditions. This study reports the first evoked (stimulus-locked) cognitive activity with changes in amplitude across pial surface distances as small as 400 mu m, potentially enabling basic neurophysiology studies at the scale of neural micro-circuitry.