Turnover in vivo of lactosyl-ceramide and other glycosphingolipids in the adult rat brain.
Turnover in vivo of lactosyl-ceramide and other glycosphingolipids in the adult rat brain.
复制标题
成年大鼠大脑中乳糖基神经酰胺和其他鞘糖脂的体内周转。
DOI：
10.1111/j.1471-4159.1981.tb02414.x
复制
发表时间：
1981
影响因子：
4.7
通讯作者：
Barkai,AI
中科院分区：
文献类型：
--
作者：
Barkai,AI
采用半室模型研究了葡萄糖对成年大鼠脑内乳糖神经酰胺和其他鞘糖脂生物合成的定量贡献。计算了葡萄糖碳在总碳库和脂质残馀碳水化合物中的半衰期。在所有糖脂中，碳水化合物单位的半衰期比相同脂质总碳库中碳的半衰期短6 ~ 8倍。碳水化合物的半衰期似乎与糖脂的周转率密切相关。糖基神经酰胺的碳水化合物半衰期最短（2.2天），其次是神经节苷脂。半乳糖-神经酰胺和硫化物。结果表明，乳糖神经酰胺可能作为脑神经节苷脂生物合成的分支点，而不是作为更复杂分子的分解产物发生。
The quantitative contribution of glucose to the biosynthesis of lactosyl‐ceramide and other glycosphingolipids was studied in the adult rat brainin vivousing a semicompartmental model. Half‐lives of glucose carbon in both the total carbon pool and the carbohydrate residue of the lipid were calculated. In all glycolipids the half‐life of carbohydrate units was six to eight times shorter than the half‐life of carbon in the total carbon pool of the same lipid. This carbohydrate half‐life appears to be closely related to the turnover rate of the glycolipid. The shortest carbohydrate half‐life (2.2 days) was obtained for lactosyl‐ceramide followed by gangliosides. galactosyl‐ceramides, and sulphatides. The results indicate that lactosyl‐ceramide may serve as a branch point for the biosynthesis of cerebral gangliosidesin vivorather than occur as a breakdown product of more complex molecules.