Are the average gait speeds during the 10meter and 6minute walk tests redundant in Parkinson disease?
Are the average gait speeds during the 10meter and 6minute walk tests redundant in Parkinson disease?
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DOI：
10.1016/j.gaitpost.2016.11.033
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发表时间：
2017-02
期刊：
影响因子：
2.4
通讯作者：
Earhart GM
中科院分区：
文献类型：
--
作者：
Duncan RP;Combs-Miller SA;McNeely ME;Leddy AL;Cavanaugh JT;Dibble LE;Ellis TD;Ford MP;Foreman KB;Earhart GM
我们调查了346名帕金森病（PD）患者的10米步行试验（舒适和快速）和6分钟步行试验（6 MWT）收集的平均步态速度之间的关系，以及这些关系如何随着疾病严重程度的增加而变化。Pearson相关性和线性回归分析确定了整个样品和由Hoehn & Yahr（H&Y）阶段I（n=53）、II（n=141）、III（n=135）和IV（n=17）分层的子样品的10米步行测试和6 MWT步态速度值之间的关系。我们假设冗余测试将是高度和显著相关的（即r > 0.70，p < 0.05），并且将具有线性回归模型斜率为1，截距为0。对于整个样本，6 MWT步态速度与舒适10米步行测试（r=0.75）和快速10米步行测试（r=0.79）步态速度显著相关（p<0.001），分别解释了6 MWT步态速度的56%和62%的方差。通过舒适10米步行步态速度预测的6 MWT步态速度的回归模型分别产生接近1和0的斜率和截距值，特别是对于H&Y阶段II-IV的参与者。相比之下，对于快速10米步行测试，斜率和截距值分别远离1和0。舒适10米步行试验和6 MWT步态速度在中度至重度PD患者中似乎是多余的，这表明舒适10米步行试验可用于估计该人群的6 MWT距离。
We investigated the relationships between average gait speed collected with the 10 Meter Walk Test (Comfortable and Fast) and 6 Minute Walk Test (6MWT) in 346 people with Parkinson disease (PD) and how the relationships change with increasing disease severity. Pearson correlation and linear regression analyses determined relationships between 10 Meter Walk Test and 6MWT gait speed values for the entire sample and for sub-samples stratified by Hoehn & Yahr (H&Y) stage I (n=53), II (n=141), III (n=135) and IV (n=17). We hypothesized that redundant tests would be highly and significantly correlated (i.e. r > 0.70, p < 0.05) and would have a linear regression model slope of 1 and intercept of 0. For the entire sample, 6MWT gait speed was significantly (p<0.001) related to the Comfortable 10 Meter Walk Test (r=0.75) and Fast 10 Meter Walk Test (r=0.79) gait speed, with 56% and 62% of the variance in 6MWT gait speed explained, respectively. The regression model of 6MWT gait speed predicted by Comfortable 10 Meter Walk gait speed produced slope and intercept values near 1 and 0, respectively, especially for participants in H&Y stages II–IV. In contrast, slope and intercept values were further from 1 and 0, respectively, for the Fast 10 Meter Walk Test. Comfortable 10 Meter Walk Test and 6MWT gait speeds appeared to be redundant in people with moderate to severe PD, suggesting the Comfortable 10 Meter Walk Test can be used to estimate 6MWT distance in this population.