The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.
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诱导T细胞调节(ITreg)细胞可由外周树突状细胞(DC)产生，介导T细胞对抗原再攻击的无反应。这种iTreg细胞发挥功能所需的分子因素尚不清楚。我们报道了iTregs细胞中转录辅助因子同源域唯一蛋白(Hop，也称为Hopx)在体内介导T细胞无反应性的关键作用。Hopx充足的iTreg细胞下调AP-1复合体的表达，并抑制其他T细胞。在没有Hopx的情况下，iTreg细胞表达高水平的AP-1复合体，增殖并无法介导T细胞对抗原重新攻击的无反应。因此，在体内，在DC诱导的Treg细胞的功能和促进DC介导的T细胞无应答中，Hopx是必需的。
Induced T regulatory (iTreg) cells can be generated by peripheral dendritic cells (DCs) that mediate T cell-unresponsiveness to re-challenge with antigen. The molecular factors required for the function of such iTreg cells remain unknown. We report a critical role for the transcription co-factor Homeodomain only protein (Hop, also know as Hopx) in iTregs cells to mediate T cell unresponsiveness in vivo. Hopx-sufficient iTreg cells down-regulate the expression of the AP-1 complex and suppress other T cells. In the absence of Hopx, iTreg cells express high levels of the AP-1 complex, proliferate and fail to mediate T cell-unresponsiveness to re-challenge with antigen. Thus, Hopx is required for the function of Treg cells induced by DCs and the promotion of DC-mediated T cell unresponsiveness in vivo.