Hemolysin is required for extraintestinal dissemination of Listeria monocytogenes in intragastrically inoculated mice.
Hemolysin is required for extraintestinal dissemination of Listeria monocytogenes in intragastrically inoculated mice.
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溶血素是单核细胞增生李斯特菌在胃内接种的小鼠中肠外传播所必需的。
DOI：
10.1128/iai.58.9.3147-3150.1990
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发表时间：
1990
影响因子：
3.1
通讯作者：
Czuprynski,CJ
中科院分区：
文献类型：
--
作者：
Roll,JT;Czuprynski,CJ
在这项研究中，我们证明单核细胞增生李斯特氏菌的溶血菌株（而非其衍生的非溶血突变株）在小鼠胃内接种后大量易位至肠系膜淋巴结、脾脏和肝脏。接种前在 4°C 下生长不会增加非溶血突变体的毒力。这些结果表明，单核细胞增生利斯特氏菌通过胃肠道产生毒力需要溶血活性，正如之前肠胃外攻击所显示的那样。
In this study we demonstrated that a hemolytic strain of Listeria monocytogenes, but not a nonhemolytic mutant derived from it, translocated in substantial numbers to the mesenteric lymph nodes, spleen, and liver after intragastric inoculation of mice. Growth at 4 degrees C prior to inoculation did not increase the virulence of the nonhemolytic mutant. These results indicate that hemolytic activity is required for the virulence of L. monocytogenes via the gastrointestinal tract, as has been shown previously for parenteral challenge.