The Diffusion of Perturbations in a Model of Coupled Random Boolean Networks
The Diffusion of Perturbations in a Model of Coupled Random Boolean Networks
复制标题
耦合随机布尔网络模型中扰动的扩散
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
A. Colacci
中科院分区：
文献类型：
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作者：
R. Serra;M. Villani;Chiara Damiani;Alex Graudenzi;A. Colacci
复杂系统科学的主要目标之一是揭示复杂系统各组成部分之间的相互作用对系统整体行为的影响。我们在这项工作中提出的模型是一个二维正方形元胞自动机，其每个单元被一个完整的随机布尔网络所占据。随机布尔网络是基因调控网络的一种众所周知的简化模型，因此，这种相互作用的RBN模型可以被视为组织或单克隆菌落的简化模型。这里模拟了细胞与细胞之间的相互作用机制，让特定网络的一些节点受到属于其相邻细胞的一些节点的状态的影响。研究复杂系统的整体动力学的一种可能方法是研究其对扰动的响应。我们的分析遵循这种方法论。尽管系统的动力学远非微不足道，但我们可以清楚地表明相互作用如何影响动力学和整体有序度。
Deciphering the influence of the interaction among the constituents of a complex system on the overall behaviour is one of the main goals of complex systems science. The model we present in this work is a 2D square cellular automaton whose of each cell is occupied by a complete random Boolean network. Random Boolean networks are a well-known simplified model of genetic regulatory networks and this model of interacting RBNs may be therefore regarded as a simplified model of a tissue or a monoclonal colony. The mechanism of cell-to-cell interaction is here simulated letting some nodes of a particular network being influenced by the state of some nodes belonging to its neighbouring cells. One possible means to investigate the overall dynamics of a complex system is studying its response to perturbations. Our analyses follow this methodological approach. Even though the dynamics of the system is far from trivial we could show in a clear way how the interaction affects the dynamics and the global degree of order.