Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes
Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes
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DOI：
10.1016/j.bbapap.2005.08.027
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发表时间：
2005-12-30
影响因子：
3.2
通讯作者：
Endicott, J
中科院分区：
文献类型：
--
作者：
Doerig, C;Billker, O;Endicott, J
人们对蛋白激酶作为癌症和神经退行性疾病等疾病化疗干预靶点的兴趣激增，促使人们开展研究，以确定这类酶是否也可以被视为寄生虫引起的疾病的靶标。在这里，我们概述了这一领域的最新发展，集中于(I)一些寄生虫基因组数据库的可用性所获得的好处，(Ii)针对寄生虫蛋白激酶的结构辅助设计的新兴领域，(Iii)被称为传递阻断的概念，根据该概念，在其节肢动物载体中涉及寄生虫发育的蛋白激酶可能被靶向干扰疾病的传播，以及(Iv)通过抑制建立寄生虫感染所需的宿主细胞蛋白激酶来控制寄生虫病的可能性。(C)2005 Elsevier B.V.保留所有权利。
The surge of interest in protein kinases as targets for chemotherapeutic intervention in a number of diseases such as cancer and neurodegenerative disorders has stimulated research aimed at determining whether enzymes of this class might also be considered as targets in the context of diseases caused by parasitic protists. Here, we present an overview of recent developments in this field, concentrating (i) on the benefits gained from the availability of genomic databases for a number of parasitic protozoa, (ii) on the emerging field of structure-aided design of inhibitors targeting protein kinases of parasitic protists, (iii) on the concept known as transmission-blockade, whereby kinases implicated in the development of the parasite in their arthropod vector might be targeted to interfere with disease transmission, and (iv) on the possibility of controlling parasitic diseases through the inhibition of host cell protein kinases that are required for the establishment of infection by the parasites. (c) 2005 Elsevier B.V. All rights reserved.