A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice
A Th1-recognized peptide P277, when tandemly repeated, enhances a Th2 immune response toward effective vaccines against autoimmune diabetes in nonobese diabetic mice
复制标题
Th1 识别肽 P277 在串联重复时可增强非肥胖糖尿病小鼠对有效抗自身免疫性糖尿病疫苗的 Th2 免疫反应
DOI：
10.4049/jimmunol.180.1.58
复制
发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Liu, Jingjing
中科院分区：
文献类型：
--
作者：
Jin, Liang;Zhu, Aihua;Liu, Jingjing
Subunit immunogens containing tandemly repeated copies of T and B cell epitopes have been shown to be more immunogenic than the respective immunogen containing only a single copy of the sequence. To investigate whether the increased copies of the Th2-activated peptide sequence will enhance the Th2-like immune response, we compared the cytokine secreted in mice that inoculated with two immunogens containing one or six tandemly repeated copies of a Th2-activated peptide sequence P277. Immunization of mice with a 6xP277 fusion protein elicited much higher levels of Th2-type cytokines and lower Th1-type cytokines than with a fusion protein with one P277 peptide. The data of tandemly repeated peptide P277 potentiate the anti-inflammatory in NOD mice, most likely associated with a Th1 to Th2 cytokine shift specific for the autoimmune T cells, which suggested that application of multiple tandem repeats of a Th2-activated epitope is an efficient method to enhance the anti, immune response by shifting the immune response from Th1-like to Th2-like. The subunit immunogens containing inflammatory tandemly repeated copies of peptide P277 might be effective vaccines against autoimmune diabetes in NOD mice.
