Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
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DOI：
10.1016/j.gendis.2018.05.001
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发表时间：
2018-06
期刊：
影响因子：
6.8
通讯作者：
Ren G
中科院分区：
文献类型：
--
作者：
Feng Y;Spezia M;Huang S;Yuan C;Zeng Z;Zhang L;Ji X;Liu W;Huang B;Luo W;Liu B;Lei Y;Du S;Vuppalapati A;Luu HH;Haydon RC;He TC;Ren G
乳腺癌是世界范围内妇女最常见的癌症，在全球范围内构成了一个巨大的公共卫生挑战。乳腺癌由一组起源于乳房的生物学和分子异质性疾病组成。虽然与这种癌症相关的危险因素与其他癌症有关，但遗传易感性，最明显的是BRCA1或BRCA2基因突变，是这种恶性肿瘤的重要致病因素。乳腺癌可以起源于乳腺的不同部位，如导管、小叶或两者之间的组织。在各种各样的乳腺癌中，根据其相对于原发肿瘤部位的侵袭性，乳腺癌有不同的标记类型。区分不同亚型是很重要的，因为它们具有不同的预后和治疗意义。由于在分子水平上正常发育和乳腺癌进展之间存在显著的相似之处，因此有人假设乳腺癌可能来源于乳腺癌干细胞。正常乳腺发育和乳腺干细胞受雌激素受体（er）、HER2和Wnt/β-catenin信号通路等多种信号通路调控，这些信号通路控制着干细胞增殖、细胞死亡、细胞分化和细胞运动。此外，新出现的证据表明，表观遗传调控和非编码rna可能在乳腺癌的发展中发挥重要作用，并可能导致乳腺癌的异质性和转移性，特别是对于三阴性乳腺癌。本文综述了乳腺癌的分子、细胞和遗传方面的全面研究。
As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public health challenge on a global scale. Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast. While the risk factors associated with this cancer varies with respect to other cancers, genetic predisposition, most notably mutations in BRCA1 or BRCA2 gene, is an important causative factor for this malignancy. Breast cancers can begin in different areas of the breast, such as the ducts, the lobules, or the tissue in between. Within the large group of diverse breast carcinomas, there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor sites. It is important to distinguish between the various subtypes because they have different prognoses and treatment implications. As there are remarkable parallels between normal development and breast cancer progression at the molecular level, it has been postulated that breast cancer may be derived from mammary cancer stem cells. Normal breast development and mammary stem cells are regulated by several signaling pathways, such as estrogen receptors (ERs), HER2, and Wnt/β-catenin signaling pathways, which control stem cell proliferation, cell death, cell differentiation, and cell motility. Furthermore, emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer. This review provides a comprehensive survey of the molecular, cellular and genetic aspects of breast cancer.
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DOI：
10.2147/bctt.s111394
发表时间：
2017
期刊：
Breast cancer (Dove Medical Press)
影响因子：
--
作者：
Apostolou P;Papasotiriou I
通讯作者：
Papasotiriou I
影响因子：
7.4
作者：
Asano Y;Kashiwagi S;Goto W;Takada K;Takahashi K;Morisaki T;Fujita H;Takashima T;Tomita S;Ohsawa M;Hirakawa K;Ohira M
通讯作者：
Ohira M
影响因子：
16.6
作者：
Ali MM;Akhade VS;Kosalai ST;Subhash S;Statello L;Meryet-Figuiere M;Abrahamsson J;Mondal T;Kanduri C
通讯作者：
Kanduri C
影响因子：
8
作者：
Barker, KT;Jackson, LE;Crompton, MR
通讯作者：
Crompton, MR
影响因子：
3.5
作者：
Allison, Kimberly H.
通讯作者：
Allison, Kimberly H.