Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis?
Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis?
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DOI：
10.1016/j.mehy.2015.03.006
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发表时间：
2015-06-01
影响因子：
4.7
通讯作者：
Bartold, P. M.
中科院分区：
文献类型：
--
作者：
Bright, R.;Proudman, S. M.;Bartold, P. M.
几十年来，人们已经认识到牙周病和类风湿关节炎在炎症反应和病理上的显著相似性。然而，这两种疾病是如何相互关联的还不太清楚。在类风湿关节炎的发病过程中，在类风湿关节炎的临床表现之前有一个临床前免疫阶段。在这一阶段，血清自身抗体在类风湿关节炎的临床症状和体征变得明显之前出现很多年。迄今为止，研究最好的两种自身抗体是类风湿因子和抗瓜氨酸化蛋白抗体（ACPA）。其中，ACPA的产生被认为是非常重要的，因为它们对类风湿关节炎的未来表现具有很高的预测价值。瓜氨酸化是一种常见的蛋白质翻译后修饰，基于酶将精氨酸转化为瓜氨酸。关节外瓜氨酸化和ACPA的产生，作为一种启动免疫经验，在许多组织中都有很好的记录，包括与牙周病相关的炎症牙龈组织。最近，蛋白质的氨甲酰化也以类似瓜氨酸化的方式与类风湿关节炎的发病机制有关。氨甲酰化是一种蛋白质的翻译后修饰，通过赖氨酸残基的酶独立修饰，随后诱导自身抗体。在本文中，我们假设，与牙龈炎和牙周炎相关的牙龈炎症过程中的瓜氨酸化、氨基甲酰化蛋白和相关抗体的产生可能在类风湿关节炎的发病机制中发挥作用。(c) 2015 Elsevier Ltd.版权所有。
The remarkable similarity in inflammatory response and pathology of periodontal disease and rheumatoid arthritis has been recognized for several decades. However, how these two disease may be interrelated has been less clear. During the pathogenesis of rheumatoid arthritis there is a preclinical immunological phase which precedes the clinical manifestation of rheumatoid arthritis. During this phase serum autoantibodies appear many years before the clinical signs and symptoms of rheumatoid arthritis become apparent. To date, the two best studied autoantibodies have been rheumatoid factor and anti-citrullinated protein antibodies (ACPA). Of these the production of ACPA has been considered very important due to their high predictive value in future manifestation of rheumatoid arthritis. Citrullination is a common post-translational modification of proteins based on the enzymatic conversion of arginine into citrulline. Extra-articular citrullination and production of ACPA, as a priming immunological experience, is well documented in many tissues including the inflamed gingival tissues associated with periodontal disease. More recently, carbamylation of proteins has also been implicated in the pathogenesis of rheumatoid arthritis in a manner similar to citrullination. Carbamylation is a post translational modification of proteins by an enzyme-independent modification of lysine residues against which autoantibodies are subsequently induced. In this article we hypothesise that, like citrullination, carbamylation of proteins and associated antibody production during the gingival inflammation associated with gingivitis and periodontitis may play a role in the pathogenesis of rheumatoid arthritis. (c) 2015 Elsevier Ltd. All rights reserved.