Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: a long‐term follow‐up
Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: a long‐term follow‐up
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急性淋巴细胞白血病的染色体和其他预后因素：长期随访
DOI：
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发表时间：
1989
影响因子：
6.5
通讯作者：
S. Lawler
中科院分区：
文献类型：
--
作者：
L. Secker;J. Chessells;E. Stewart;G. Swansbury;S. Richards;S. Lawler
摘要对一组80例急性淋巴细胞白血病（ALL）患儿进行了至少5年半的随访，检查了诊断时的细胞遗传学、临床和实验室特征。17例（21%）具有高超二倍体的患者倾向于具有低白细胞计数和常见ALL，但其有利的结局（75%的无事件生存率）与这些因素无关。亚二倍体患者无存活，而假二倍体和正常组的预后居中。细胞遗传学分析显示了具有公认易位的患者的例子和一些具有明显独特易位的患者。其中一些是长期的幸存者。我们得出结论，细胞遗传学分析确定了长期随访保持良好的患者的良好风险组，但易位的存在并不一定意味着不良结局。
Summary. Cytogenetic, clinical and laboratory features at diagnosis were examined in a group of 80 children with acute lymphoblastic leukaemia (ALL) who had been followed up for a minimum of 5 1/2 years. The 17 (21%) with high hyperdiploidy tended to have low leucocyte counts and common ALL, but their favourable outcome (75% event‐free survival) was independent of these factors. No patient with hypodiploidy survives while the pseudodiploid and normal groups have an intermediate prognosis. Cytogenetic analysis showed examples of patients with the well‐recognized translocations and a number with apparently unique ones. Among the latter were some long‐term survivors. We conclude that Cytogenetic analysis identifies a good risk group of patients who remain well on long‐term follow‐up, but that the presence of a translocation does not necessarily imply a poor outcome.
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