Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
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DOI：
10.1038/nri2327
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发表时间：
2008-06-01
影响因子：
100.3
通讯作者：
Tsai, Mindy
中科院分区：
文献类型：
--
作者：
Galli, Stephen J.;Grimbaldeston, Michele;Tsai, Mindy
肥大细胞可以促进IgE相关过敏性疾病中的炎症和其他组织变化，以及被认为不依赖于IgE的某些先天性和适应性免疫应答。然而，肥大细胞也可以具有抗炎和免疫抑制功能。在这里，我们回顾的证据表明，肥大细胞可以有负面的，以及积极的，在体内的免疫调节作用，我们提出，肥大细胞可以增强和后来抑制某些功能的免疫反应。
Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.