Palladium-catalyzed addition of nitrogen pronucleophiles to alkylidenecyclopropanes.
Palladium-catalyzed addition of nitrogen pronucleophiles to alkylidenecyclopropanes.
复制标题
DOI：
10.1021/jo050700s
复制
发表时间：
2005-06
期刊：
影响因子：
--
通讯作者：
Amal Siriwardana;Michiru Kamada;I. Nakamura;Yoshinori Yamamoto
中科院分区：
文献类型：
--
作者：
Amal Siriwardana;Michiru Kamada;I. Nakamura;Yoshinori Yamamoto
在Pd(PPh(3))(4)的催化作用下，环酰胺（氮亲核试剂）在亚甲基环丙烷分子间和分子内的加成过程顺利进行，相应的氢胺化产物收率高，具有高的区域选择性。亚甲基环丙烷的开环发生在环丙烷环的远端位置。
The inter- and intramolecular additions of cyclic amides (nitrogen pronucleophiles) to methylenecyclopropanes proceeded smoothly in the presence of catalytic amounts of Pd(PPh(3))(4), affording the corresponding hydroamination products in good to high yields with high regioselectivities. The ring opening of methylenecyclopropanes occurred at the distal position of the cyclopropane ring.