Persistence of metabolic rhythmicity during fasting and its entrainment by restricted feeding schedules in rats
Persistence of metabolic rhythmicity during fasting and its entrainment by restricted feeding schedules in rats
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DOI：
10.1152/ajpregu.1998.274.5.r1309
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发表时间：
1998-05-01
影响因子：
2.8
通讯作者：
Aguilar-Roblero, R
中科院分区：
文献类型：
--
作者：
Escobar, C;Díaz-Muñoz, M;Aguilar-Roblero, R
现在，独立于SCN的食物携带振荡器(FEO)的存在已经得到了很好的证实，但到目前为止，它的位置和特征一直难以捉摸。因为它的表达需要启动动物的新陈代谢进入分解代谢状态，所以代谢节律可能与FEO有关。本研究旨在确定禁食期间代谢节律是否持续，以及这种节律是否会受到限制的进食时间表的影响。结果表明，禁食期间三酰甘油、游离脂肪酸、葡萄糖和蛋白质的持续节律，而酮体和肝糖原的浓度随着禁食的变化而变化。每天2小时的食物脉冲影响了三酰甘油和游离脂肪酸的节律，并将酮体和肝糖原恢复到类似的水平作为对照。无论是葡萄糖还是蛋白质都不会受到食物脉冲的影响。这些结果表明脂代谢是与FEO相关的现象。
The presence of a food-entrainable oscillator (FEO) independent from the SCN is now well established, but until now its location and characterization have been elusive. Because its expression requires priming of the animal's metabolism toward a catabolic state, it is possible that metabolic rhythms may be related to FEO. The present study was designed to determine whether metabolic rhythms persist during fasting and whether such rhythms could be entrained to a restricted feeding schedule. The results indicate persistent rhythms of triacylglycerides, free fatty acids, glucose, and proteins during fasting, whereas ketone bodies and liver glycogen changed their concentration as a function of fasting. Daily food pulses of 2 h entrained the rhythms of triacylglycerides and free fatty acids and restored ketone bodies and liver glycogen to similar levels as controls. Neither glucose nor proteins were affected by the food pulse. These results indicate the relevance of lipid metabolism as a phenomenon associated with the FEO.