Mammalian phospholipase A2:: Phospholipase A2 receptor
Mammalian phospholipase A2:: Phospholipase A2 receptor
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DOI：
10.1248/bpb.27.1165
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发表时间：
2004-08-01
影响因子：
2
通讯作者：
Hanasaki, K
中科院分区：
文献类型：
--
作者：
Hanasaki, K
The phospholipase A(2) receptor (PLA(2)R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA(2)R regulates a variety of biological responses elicited by secretory phospholipase A(2)s (sPLA(2)S). Group IB sPLA(2) acts as an endogenous ligand to induce cell proliferation and lipid mediator production. Analysis of PLA(2)R-deficient mice suggested a potential role of the sPLA(2)-IB/PLA(2)R pathway in the production of proinflammatory cytokines during endotoxic shock. PLA(2)R is also involved in the clearance of sPLA(2)s, especially group X sPLA(2), to protect their exaggerated reactions by potent enzymatic activities. In circulation, the soluble form of PLA(2)R is constitutively present as an endogenous inhibitor for mammalian sPLA(2)s.
