History of sudden unexpected loss is associated with elevated interleukin-6 and decreased insulin-like growth factor-1 in women in an urban primary care setting.
History of sudden unexpected loss is associated with elevated interleukin-6 and decreased insulin-like growth factor-1 in women in an urban primary care setting.
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城市初级保健机构中女性的突然意外丢失史与白细胞介素 6 升高和胰岛素样生长因子 1 降低有关。
DOI：
10.1097/psy.0b013e3181be7aa8
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发表时间：
2009
影响因子：
3.3
通讯作者：
Duberstein,PaulR
中科院分区：
文献类型：
--
作者：
Cankaya,Banu;Chapman,BenjaminP;Talbot,NancyL;Moynihan,Jan;Duberstein,PaulR
目的：调查突然意外损失的历史，包括损失的数量和损失的类型（由于非自然原因与自然原因导致的死亡）与失调程度相关的假设。亲人的突然意外死亡会带来发病和死亡的风险，可能是由于免疫/炎症和内分泌系统的失调。方法：年龄≥40岁的女性初级保健患者（n= 75）完成问卷调查、临床访谈和抽血。白细胞介素(IL)-6和胰岛素样生长因子(IGF)-1采用标准的酶联免疫吸附试验方案和抗细胞因子抗体对进行检测。结果：突然丢失史与IL-6呈正相关（平均= 4.07 pg/mL， log 10值，B= 0.314, p= 0.314）。009)，与IGF-1呈负相关(平均= 97.05 ng/mL； B= - 0.277, p=。023)。线性关系简洁地捕获了有序类别寿命损失（0,1,2,5,5 +）与log 10 IL-6增加之间的关联（B= 0.107, p=）。005)， IGF-1降低(B= - 0.116, p=。005)。调整疾病负担、抑郁症状严重程度和肥胖并没有改变观察到的关联。损失类型效应的假设不被支持。结论：这些初步发现鼓励进一步的研究，以阐明从突然的意外损失到增加发病率和死亡率风险的生物标志物变化的途径。
Objective:To investigate the hypothesis that a history of sudden unexpected loss including number of losses and type of loss (death due to unnatural versus natural causes) would be associated with the magnitude of dysregulation. The sudden unexpected death of a loved one confers risk of morbidity and mortality, perhaps due to dysregulation in the immune/inflammatory and endocrine systems.Methods:Female primary care patients aged≥ 40 years (n= 75) completed questionnaires, a clinical interview, and a blood draw. Interleukin (IL)-6 and insulin-like growth factor (IGF)-1 were assayed, using standard enzyme-linked immunosorbent assay protocols and anticytokine antibody pairs.Results:History of sudden loss was positively associated with IL-6 (mean= 4.07 pg/mL; log 10 values, B= 0.314, p=. 009) and negatively associated with IGF-1 (mean= 97.05 ng/mL; B=− 0.277, p=. 023). A linear relationship parsimoniously captured the association between ordered categories of lifetime loss (0, 1, 2–5, 5+) and increases in log 10 IL-6 (B= 0.107, p=. 005) and decreases in IGF-1 (B=− 0.116, p=. 005). Adjusting for illness burden, depressive symptom severity, and obesity did not change the observed associations. The hypothesized effect of type of loss was not supported.Conclusions:These preliminary findings encourage further investigations to elucidate pathways from sudden unexpected loss to biomarker changes that increase risk for morbidity and mortality.