ENERGY-COST OF WALKING AND EXERTIONAL DYSPNEA IN MULTIPLE-SCLEROSIS
ENERGY-COST OF WALKING AND EXERTIONAL DYSPNEA IN MULTIPLE-SCLEROSIS
复制标题
DOI：
10.1164/arrd.1986.134.5.1005
复制
发表时间：
1986-11-01
期刊：
影响因子：
--
通讯作者：
DIPRAMPERO, PE
中科院分区：
文献类型：
--
作者：
OLGIATI, R;JACQUET, J;DIPRAMPERO, PE
对24例多发性硬化症患者(P)静息时的肺功能和低速跑台步行时的心肺功能进行了研究，并与对照组(C)进行了比较。静息时，P组残气量/TLC比值增加21%，呼吸肌力指数降低28%，心率(HR)增加11次/−。在跑步机上以给定速度行走时，心率、每分钟通气量和氧耗量均升高(37%~119%)。此外，静息以上单位距离步行的能量成本是安静时的2~3倍，2公里/小时时P为0.299±0.019，C为0.147±0.006，4公里/小时时分别为0.275±0.042和0.110±0.005(P和C分别为01 kg−1M−1)，HR和也参考给定的参考时更高。我们的结论是，步行的高能量成本可能是多发性硬化症患者呼吸困难和腿部疲劳的重要因素。调节不良、心血管控制改变和呼吸肌无力可能起到额外的作用。
Pulmonary functions at rest and cardiorespiratory responses to low speed treadmill walking were investigated in 24 patients (P), (mean age, 38 years; range, 20 to 56 yr) with multiple sclerosis and compared with a control group (C). The following parameters were significantly (p < 0.01) different in P from those in C. At rest in P, the residual volume to TLC ratio was 21% greater, respiratory muscle strength index was 28% lower, and heart rate (HR) was 11 beats/min−1higher. During treadmill walking at a given speed, HR, minute ventilation , and O2consumption were all elevated (37 to 119%). In addition, the energy cost of walking, per unit distance, above resting, was 2 to 3 times greater, with mean ± SEM values for P of 0.299 ± 0.019 and C of 0.147 ± 0.006 at 2 km/h and 0.275 ± 0.042 and 0.110 ± 0.005 (for P and C, respectively) ml O1kg−1m−1at 4 km/h; the HR and , also when referred to a given , were higher. We conclude that a high energy cost of walking may be an important contributing factor to breathlessness and leg fatigue in patients with multiple sclerosis. Poor conditioning, altered cardiovascular control, and respiratory muscle weakness may play additional roles.