The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice
The inflammatory response in interleukin-1 beta-deficient mice: Comparison with other cytokine-related knock-out mice
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DOI：
10.1002/jlb.59.4.489
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发表时间：
1996-04-01
影响因子：
5.5
通讯作者：
Dinarello, CA
中科院分区：
文献类型：
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作者：
Fantuzzi, G;Dinarello, CA
白介素1(IL-1)在感染和炎症反应的病理生理过程中起着至关重要的作用。然而，IL-1α和IL-1β的相对贡献尚不清楚。IL-1β缺陷小鼠是研究IL-1β在各种实验条件下的具体作用的有力工具。在这份报告中，我们总结了IL-1β缺陷小鼠对两种不同的炎症刺激，松节油和内毒素的反应。尽管IL-1β缺陷小鼠对全身注射脂多糖(LPS)的反应正常，但在松节油注射的局部组织损伤模型中，它们没有出现急性时相反应。使用IL-1β缺陷小鼠获得的结果与在IL-1β转换酶缺陷小鼠、IL-6缺陷小鼠、肿瘤坏死因子受体P55缺陷小鼠和干扰素γ受体缺陷小鼠中观察到的结果进行了比较。
Interleukin-1 (IL-1) plays a crucial role in the development of the pathophysiological responses to infection and inflammation. However, the relative contributions of IL-1 alpha and IL-1 beta remain to be clarified. IL-1 beta-deficient mice are a powerful tool to investigate the specific role of IL-1 beta in various experimental conditions. In this report, we summarize the response of IL-1 beta-deficient mice to two different inflammatory stimuli, turpentine and endotoxin. Although IL-1 beta-deficient mice respond normally to the systemic administration of lipopolysaccharide (LPS), they do not develop an acute-phase response in the localized tissue damage model of turpentine injection. The results obtained using the IL-1 beta-deficient mice are compared here with those observed in the IL-1 beta-converting enzyme-deficient, IL-6-deficient, tumor necrosis factor-receptor p55-deficient, and interferon-gamma-receptor-deficient mice.