Change over time in brain serotonin transporter binding in major depression: effects of therapy measured with [(123) I]-ADAM SPECT.
Change over time in brain serotonin transporter binding in major depression: effects of therapy measured with [(123) I]-ADAM SPECT.
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DOI：
10.1111/jon.12035
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Soeller I
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文献类型：
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作者：
Amsterdam JD;Newberg AB;Newman CF;Shults J;Wintering N;Soeller I
多项研究报告称，重度抑郁症患者的脑血清素转运蛋白（SERT）结合率较低。我们假设，与认知行为治疗（CBT）无应答者相比，使用[123 I]-ADAM单光子发射计算机断层扫描的SERT标准化摄取率（SUR）值在对CBT有应答的抑郁受试者中会增加。[123 I]-ADAM扫描在12周CBT之前和之后从20名抑郁症受试者中获得，并在12周内从10名非抑郁症健康志愿者中获得两次。主要结果指标是中脑、内侧颞叶和基底节区SUR值随时间的变化。抑郁受试者表现出较低的治疗前平均SUR值，在中脑（p=0.011）、右内侧颞叶（p=0.008）和左内侧颞叶（p=0.000）区域随时间显著增加。治疗应答者显示左内侧颞叶（p=0.029）和右内侧颞叶（p=0.007）区域的SUR值随时间显著增加。部分和无应答受试者的左内侧颞区SUR值也随时间显著增加（p=0.040）（与健康志愿者相比），但程度较轻。研究结果表明，低治疗前SERT结合可能会随着时间的推移增加，在一些抑郁症患者谁经历症状改善。
Several studies have reported low brain serotonin transporter (SERT) binding in individuals with major depression. We hypothesized that the SERT standardized uptake ratio (SUR) values using [123I]-ADAM single photon emission computed tomography would increase in depressed subjects who responded to cognitive behavior therapy (CBT) compared to CBT nonresponders. [123I]-ADAM scans were acquired before and after 12 weeks of CBT from 20 depressed subjects and on two occasions 12 weeks apart from 10 non-depressed, healthy volunteers. The primary outcome measure was change over time in SUR values in the midbrain, medial temporal lobe, and basal ganglia regions. Depressed subjects demonstrated low pre-treatment mean SUR values that significantly increased over time in the midbrain (p=0.011), right medial temporal lobe (p=0.008), and left medial temporal lobe (p=0.000) regions. Treatment responders showed a significant increase over time in SUR values in left medial temporal lobe (p=0.029) and right medial temporal lobe (p=0.007) regions. Partial and nonresponder subjects also showed a significant increase over time in SUR values in the left medial temporal region (p=0.040) (versus healthy volunteers), but to a lesser degree. The findings suggest that low pre-treatment SERT binding may increase over time in some depressed individuals who experience symptom improvement.