Current concepts of pharmacotherapy in hypertension: thiazide-type diuretics: ongoing considerations on mechanism of action.
Current concepts of pharmacotherapy in hypertension: thiazide-type diuretics: ongoing considerations on mechanism of action.
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DOI：
10.1111/j.1524-6175.2004.03902.x
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发表时间：
2004-11-01
期刊：
影响因子：
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通讯作者：
Sica, Domenic A
中科院分区：
文献类型：
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作者：
Sica, Domenic A
噻嗪类利尿剂在高血压的治疗中取得了相当大的成功。这些药物在许多卫生保健提供者的心目中已被视为护理标准；然而，与其使用有关的一些问题仍未得到解决。这些问题包括作用机制、作用与环状利尿剂的可比性、类别效应以及它们与非利尿性抗高血压药物类别相加的基础。了解这些问题对于有效使用这些化合物很重要。
Thiazide-type diuretics have enjoyed a considerable success in the management of hypertension. These drugs have assumed a standard-of-care position in the minds of many health care providers; however, a number of questions remain unresolved in relation to their use. Such questions include issues of mechanism of action, comparability to loop-diuretics in their actions, class-effect, and the basis for their additivity with non-diuretic antihypertensive medication classes. Understanding these issues is important to the effective use of these compounds.