Adsorption mechanism of polyphenols onto starch nanoparticles and enhanced antioxidant activity under adverse conditions
Adsorption mechanism of polyphenols onto starch nanoparticles and enhanced antioxidant activity under adverse conditions
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多酚在淀粉纳米颗粒上的吸附机制及其在不利条件下增强抗氧化活性
DOI：
10.1016/j.jff.2016.08.036
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发表时间：
2016-10-01
影响因子：
5.6
通讯作者：
Sun, Qingjie
中科院分区：
文献类型：
--
作者：
Liu, Chengzhen;Ge, Shengju;Sun, Qingjie
多酚具有强大的抗氧化能力，可能会降低患慢性病的风险。然而，它们对pH、温度和光线都很敏感，限制了它们的应用。本研究开发了一种基于淀粉纳米颗粒的纳米载体，用于负载四种多酚：(+)-儿茶素、(-)-表儿茶素、(-)-表儿茶素-3-没食子酸酯和原花青素。分析了负载多酚的吸附动力学、吸附等温线、负载量、负载效率、抗氧化活性和体外释放。2，2-二苯基-1-苦基肼自由基的清除活性表明，负载多酚在离子强度、加热和紫外线照射下比游离多酚更稳定。用四甲基偶氮唑盐比色法测定其细胞毒性和良好的生物相容性。在人工胃液(pH 2.0)和肠液(pH 7.0)中，多酚类物质有缓释作用。这些发现可能导致基于SNPs作为多酚和其他生物活性化合物载体的食品配方。(C)2016爱思唯尔有限公司。保留所有权利。
Polyphenols have potent antioxidant capacities and may reduce chronic disease risk. However, they are sensitive to pH, temperature, and light, limiting their applications. This study developed a starch nanoparticle based nanocarrier on which to load four polyphenols: (+)-catechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, and proanthocyanidins. The adsorption kinetics, adsorption isotherms, loading amount, loading efficiency, antioxidant activities, and in vitro release of the loaded polyphenols were analysed. The 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity demonstrated loaded polyphenols were more stable than free polyphenols if exposed to ionic strength, heating, and ultraviolet radiation. In addition, low cytotoxicity and good biocompatibility were found as determined by methyl thiazolyl tetrazolium assay. In artificial gastric (pH 2.0) and intestinal (pH 7.0) juices, the poly phenols showed a sustained release. These findings could lead to food formulations based on SNPs as a carrier of polyphenols and other bioactive compounds. (C) 2016 Elsevier Ltd. All rights reserved.