The Cilium: Cellular Antenna and Central Processing Unit.
The Cilium: Cellular Antenna and Central Processing Unit.
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纤毛：细胞天线和中央加工单元。
DOI：
10.1016/j.tcb.2016.08.002
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发表时间：
2017-02
影响因子：
19
通讯作者：
Johnson CA
中科院分区：
文献类型：
--
作者：
Malicki JJ;Johnson CA
纤毛介导的过程惊人的多样性。最近的进展提供了意想不到的见解纤毛形成的调控机制，并揭示了不同的调控输入，与细胞周期，细胞骨架，蛋白质稳态，纤毛介导的信号本身。纤毛发生和纤毛维持受相互拮抗或协同影响的调节，通常相互平行作用。通过接收并行输入，纤毛似乎将多个信号整合到特定的输出中，并且可能具有类似于数字系统的逻辑门的功能。输入信号的某些组合似乎施加了与细胞周期相关的更高层次的控制。这些监管投入的综合观点将是必要的，以了解纤毛发生及其更广泛的相关性，人类生物学。初级纤毛将复杂的组合输入整合成输出功能。调节输入来自细胞骨架、蛋白质稳态和纤毛信号传导。细胞周期的输入导致不可逆的拆卸决定，凌驾于其他输入。纤毛中输入的整合类似于逻辑门的行为。
Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory inputs that are related to the cell cycle, cytoskeleton, proteostasis, and cilia-mediated signaling itself. Ciliogenesis and cilia maintenance are regulated by reciprocal antagonistic or synergistic influences, often acting in parallel to each other. By receiving parallel inputs, cilia appear to integrate multiple signals into specific outputs and may have functions similar to logic gates of digital systems. Some combinations of input signals appear to impose higher hierarchical control related to the cell cycle. An integrated view of these regulatory inputs will be necessary to understand ciliogenesis and its wider relevance to human biology. Primary cilia integrate complex combinatorial inputs into output functions. Modulatory inputs arise from the cytoskeleton, proteostasis, and ciliary signaling. Cell-cycle inputs lead to irreversible disassembly decisions that override other inputs. The integration of inputs in cilia resembles the behavior of logic gates.