Influenza A and febrile seizures in childhood
Influenza A and febrile seizures in childhood
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DOI：
10.1016/j.pediatrneurol.2006.07.005
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发表时间：
2006-12-01
影响因子：
3.8
通讯作者：
Wong, Sik N.
中科院分区：
文献类型：
--
作者：
Kwong, Karen L.;Lam, Shu Y.;Wong, Sik N.
本研究的目的是确定甲型流感病毒感染引起热性惊厥的易感因素，并阐明甲型流感病毒感染儿童热性惊厥的特殊性。2005年1月至7月期间，因热性惊厥住院并随后确诊为甲型流感感染的儿童入组为受试者。匹配的对照受试者是因甲型流感感染而入院但无热性惊厥的受试者（对照1）和病毒研究阴性的热性惊厥儿童（对照2）。热性惊厥发生的重要因素包括：热性惊厥史、惊厥性疾病家族史和同时存在的胃肠炎。热性惊厥的独立危险因素是热性惊厥史（比值比7.58，95%可信区间CI 1.48 - 38.84，P = 0.015）。与病毒研究阴性的热性惊厥儿童相比，甲型流感感染中发生热性惊厥的儿童最高体温显著升高，惊厥发作前发热持续时间缩短，部分性惊厥发生率更高。目前的发作是26.5%的甲型流感感染儿童首次癫痫发作，而病毒研究阴性的儿童为50%（P = 0.04）。研究结果表明，有效的疫苗接种可以预防热性惊厥的发生，特别是那些有热性惊厥病史的患者。在复杂性热性惊厥的管理中，特别是在流感季节，流感感染的快速诊断检测具有成本效益。(c)2006年，Elsevier Inc. All rights reserved.
The aims of the present study are to identify predisposing factors of febrile seizures in influenza A infection and to clarify the special characteristics of febrile seizures in children with influenza A infection. Between January and July 2005, children hospitalized because of febrile seizures and subsequently confirmed influenza A infection were enrolled as subjects. Age-matched control subjects were those admitted as a result of influenza A infection but no febrile seizures (control 1) and children who developed febrile seizures with negative viral studies (control 2). Significant factors for the development of febrile seizures include: history of febrile seizures, family history of seizure disorders, and coexisting gastroenteritis. Independent risk factor for febrile seizures was history of febrile seizures (odds ratio 7.58, 95% confidence interval CI 1.48 to 38.84, P = 0.015). When compared with children who developed febrile seizures with negative virus studies, children who developed febrile seizures in influenza A infection had a significantly higher maximum body temperature, shorter duration of fever before seizure onset, and more frequent occurrence of partial seizures. Current episode represented first seizure in 26.5% of children infected with influenza A as compared with 50% of children whose virus studies were negative (P = 0.04). The findings suggest that effective vaccination may prevent development of febrile seizures, especially in those patients with past history of febrile seizures. Rapid diagnostic testing for influenza infection in the management of complex febrile seizures, especially during influenza season, is cost-effective. (c) 2006 by Elsevier Inc. All rights reserved.