Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures
Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures
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DOI：
10.1016/s0925-4773(02)00078-3
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发表时间：
2002-06-01
影响因子：
2.6
通讯作者：
Cossu, G
中科院分区：
文献类型：
--
作者：
Broccoli, V;Colombo, E;Cossu, G
同源框基因编码一类特殊的转录因子，它们参与几个不同的发育过程，如区域身份的指定，细胞决定和增殖。特别地，在早期脑形态发生期间，它们提供遗传密码，该遗传密码在后脑中产生单个菱形体身份（Science 284（1999）2168）和在腹侧神经管中产生中间神经元特化（Nat.Rev.Genet. 1（2000）20）。我们已经分离了一个含有成对同源框的基因，最近将其命名为Dmbx1（Mech.Dev. 110（2002）241）。Dmbx 1蛋白由于其同源结构域与该家族的其他几个成员具有最高的同源性，可以被列入配对样类。除嗅觉神经元外，Dmbx 1仅在发育中的中枢神经系统中表达，特别是在中脑和间脑尾部的早期决定和连续分化期间。有趣的是，Dmbx 1表达标记小脑颗粒祖细胞在分化和脊髓V0中间神经元的开始。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Homeobox genes encode a particular class of transcription factors that are involved in several different developmental processes such as specification of regional identity, cell determination and proliferation. In particular, during early brain morphogenesis, they provide a genetic code, which generates single rhombomere identity in the hindbrain (Science 284 (1999) 2168) and interneurons specification in the ventral neural tube (Nat. Rev. Genet. 1 (2000) 20). We have isolated a paired homeobox containing gene, which has been recently named Dmbx1 (Mech. Dev. 110 (2002) 241). Dmbx1 protein can be listed into the paired-like class, due to the highest homology in its homeodomain, with several other members of this family. With the exception of olfactory neurons, Dmbx1 is expressed only in the developing central nervous system and in particular during early determination and successive differentiation of the midbrain and caudal diencephalon. Interestingly, Dmbx1 expression labels cerebellar granule progenitors at the onset of differentiation and spinal cord V0 interneurons. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.